Baclofen, raclopride, and naltrexone differentially affect intake of fat/sucrose mixtures under limited access conditions

K. J. Wong, F. H.W. Wojnicki, Rebecca L. Corwin

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

This study assessed the effects of the opioid antagonist naltrexone, the dopamine 2-like (D2) antagonist raclopride, and the GABAB agonist baclofen on consumption of fat/sucrose mixtures (FSM) using a limited access protocol. Sixty male Sprague-Dawley rats were grouped according to two schedules of access (Daily [D] or Intermittent [I]) to an optional FSM. Each FSM was created by whipping 3.2% (L), 10% (M), or 32% (H) powdered sugar into 100% vegetable shortening in a w/w manner (n = 10 per group). One-hour intakes of the IL and IM groups were significantly greater than intakes of the respective DL and DM groups, thus fulfilling our operational definition of binge-type eating in these groups. Baclofen reduced intakes of the L and M mixtures regardless of access schedule, but failed to reduce intake of the H mixture. Naltrexone reduced intake in all groups, but potency was greater in IL rats than in DL rats. Furthermore, potency was attenuated in Intermittent rats, but enhanced in Daily rats, at higher sucrose concentrations. Raclopride reduced intake in the DL and stimulated intake in the IL groups, reduced intake in both M groups, and was without effect in both H groups. These results indicate that fat/sucrose mixtures containing relatively low concentrations of sucrose allow distinctions to be made between: 1) intakes stimulated by different access schedules and 2) opioid and dopaminergic modulation of those intakes. These results also suggest that brief bouts of food consumption involving fatty, sugar-rich foods may prove to be particularly resistant to pharmacological intervention.

Original languageEnglish (US)
Pages (from-to)528-536
Number of pages9
JournalPharmacology Biochemistry and Behavior
Volume92
Issue number3
DOIs
StatePublished - May 1 2009

Fingerprint

Raclopride
Naltrexone
Baclofen
Sucrose
Fats
Rats
Appointments and Schedules
Sugars
Food
Bulimia
Narcotic Antagonists
Vegetables
Opioid Analgesics
Sprague Dawley Rats
Dopamine
Modulation
Pharmacology

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

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abstract = "This study assessed the effects of the opioid antagonist naltrexone, the dopamine 2-like (D2) antagonist raclopride, and the GABAB agonist baclofen on consumption of fat/sucrose mixtures (FSM) using a limited access protocol. Sixty male Sprague-Dawley rats were grouped according to two schedules of access (Daily [D] or Intermittent [I]) to an optional FSM. Each FSM was created by whipping 3.2{\%} (L), 10{\%} (M), or 32{\%} (H) powdered sugar into 100{\%} vegetable shortening in a w/w manner (n = 10 per group). One-hour intakes of the IL and IM groups were significantly greater than intakes of the respective DL and DM groups, thus fulfilling our operational definition of binge-type eating in these groups. Baclofen reduced intakes of the L and M mixtures regardless of access schedule, but failed to reduce intake of the H mixture. Naltrexone reduced intake in all groups, but potency was greater in IL rats than in DL rats. Furthermore, potency was attenuated in Intermittent rats, but enhanced in Daily rats, at higher sucrose concentrations. Raclopride reduced intake in the DL and stimulated intake in the IL groups, reduced intake in both M groups, and was without effect in both H groups. These results indicate that fat/sucrose mixtures containing relatively low concentrations of sucrose allow distinctions to be made between: 1) intakes stimulated by different access schedules and 2) opioid and dopaminergic modulation of those intakes. These results also suggest that brief bouts of food consumption involving fatty, sugar-rich foods may prove to be particularly resistant to pharmacological intervention.",
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Baclofen, raclopride, and naltrexone differentially affect intake of fat/sucrose mixtures under limited access conditions. / Wong, K. J.; Wojnicki, F. H.W.; Corwin, Rebecca L.

In: Pharmacology Biochemistry and Behavior, Vol. 92, No. 3, 01.05.2009, p. 528-536.

Research output: Contribution to journalArticle

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