Bacterial Mg2+ homeostasis, transport, and virulence

Eduardo A. Groisman, Kerry Hollands, Michelle A. Kriner, Eun Jin Lee, Sun Yang Park, Mauricio H. Pontes

Research output: Contribution to journalReview article

75 Citations (Scopus)

Abstract

Organisms must maintain physiological levels of Mg2+ because this divalent cation is critical for the stabilization of membranes and ribosomes, for the neutralization of nucleic acids, and as a cofactor in a variety of enzymatic reactions. In this review, we describe the mechanisms that bacteria utilize to sense the levels of Mg2+ both outside and inside the cytoplasm. We examine how bacteria achieve Mg2+ homeostasis by adjusting the expression and activity of Mg2+ transporters and by changing the composition of their cell envelope. We discuss the connections that exist between Mg2+ sensing, Mg2+ transport, and bacterial virulence. Additionally, we explore the logic behind the fact that bacterial genomes encode multiple Mg2+ transporters and distinct sensing systems for cytoplasmic and extracytoplasmic Mg2+. These analyses may be applicable to the homeostatic control of other cations.

Original languageEnglish (US)
Pages (from-to)625-646
Number of pages22
JournalAnnual review of genetics
Volume47
DOIs
StatePublished - Nov 2013

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Virulence
Homeostasis
Bacteria
Bacterial Genomes
Divalent Cations
Ribosomes
Nucleic Acids
Cations
Cytoplasm
Membranes

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Groisman, Eduardo A. ; Hollands, Kerry ; Kriner, Michelle A. ; Lee, Eun Jin ; Park, Sun Yang ; Pontes, Mauricio H. / Bacterial Mg2+ homeostasis, transport, and virulence. In: Annual review of genetics. 2013 ; Vol. 47. pp. 625-646.
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Bacterial Mg2+ homeostasis, transport, and virulence. / Groisman, Eduardo A.; Hollands, Kerry; Kriner, Michelle A.; Lee, Eun Jin; Park, Sun Yang; Pontes, Mauricio H.

In: Annual review of genetics, Vol. 47, 11.2013, p. 625-646.

Research output: Contribution to journalReview article

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AU - Park, Sun Yang

AU - Pontes, Mauricio H.

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