Bacteriophage exclusion, a new defense system

Rodolphe Barrangou, John Van Der Oost

Research output: Contribution to journalShort survey

12 Citations (Scopus)

Abstract

The ability to withstand viral predation is critical for survival of most microbes. Accordingly, a plethora of phage resistance systems has been identified in bacterial genomes (Labrie et al, 2010), including restriction-modification systems (R-M) (Tock & Dryden, 2005), abortive infection (Abi) (Chopin et al, 2005), Argonaute-based interference (Swarts et al, 2014), as well as clustered regularly interspaced short palindromic repeats (CRISPR) and associated protein (Cas) adaptive immune system (CRISPR-Cas) (Barrangou & Marraffini, 2014; Van der Oost et al, 2014). Predictably, the dark matter of bacterial genomes contains a wealth of genetic gold. A study published in this issue of The EMBO Journal by Goldfarb et al (2015) unveils bacteriophage exclusion (BREX) as a novel, widespread bacteriophage resistance system that provides innate immunity against virulent and temperate phage in bacteria.

Original languageEnglish (US)
Pages (from-to)134-135
Number of pages2
JournalEMBO Journal
Volume34
Issue number2
DOIs
StatePublished - Jan 14 2015

Fingerprint

Bacteriophages
Clustered Regularly Interspaced Short Palindromic Repeats
Bacterial Genomes
Genes
DNA Restriction-Modification Enzymes
Immune system
Innate Immunity
Gold
Immune System
Bacteria
Infection
Proteins

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Barrangou, Rodolphe ; Van Der Oost, John. / Bacteriophage exclusion, a new defense system. In: EMBO Journal. 2015 ; Vol. 34, No. 2. pp. 134-135.
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Barrangou, R & Van Der Oost, J 2015, 'Bacteriophage exclusion, a new defense system', EMBO Journal, vol. 34, no. 2, pp. 134-135. https://doi.org/10.15252/embj.201490620

Bacteriophage exclusion, a new defense system. / Barrangou, Rodolphe; Van Der Oost, John.

In: EMBO Journal, Vol. 34, No. 2, 14.01.2015, p. 134-135.

Research output: Contribution to journalShort survey

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