Abstract

Apparent competition between species is believed to be one of the principal driving forces that structure ecological communities, although the precise mechanisms have yet to be characterized. Here we develop a model system that isolates phage-mediated interactions by neutralizing resource competition with a large excess of nutrients, and consists of two genetically identical Bordetella strains that differ only in that one is the carrier of phage and the other is susceptible to the phage. We observe and quantify the competitive advantage of the bacterial strain bearing the prophage in both invading and in resisting invasion by the bacterial strain sensitive to the phage, and use our experimental measurements to develop a mathematical model of phage-mediated competition. The model predicts, and experimental evidence confirms, that the competitive advantage conferred by the lysogenic phage depends only on the phage pathology on the sensitive bacterial strain and is independent of other phage and host parameters, such as the infection-causing contact rate, the spontaneous and infection-induced lysis rates and the phage burst size. This work combines experimental and mathematical approaches to the study of phage-driven competition, and provides an experimentally tested framework for evaluation of the effects of pathogens/parasites on interspecific competition.

Original languageEnglish (US)
Pages (from-to)1843-1848
Number of pages6
JournalProceedings of the Royal Society B: Biological Sciences
Volume273
Issue number1595
DOIs
StatePublished - Jan 1 2006

Fingerprint

Bordetella
Bacteriophages
bacteriophage
bacteriophages
Bacteria
bacterium
bacteria
apparent competition
lysis
interspecific competition
pathology
parasite
pathogen
nutrient
resource
Theoretical Models
Bearings (structural)
nutrient excess
Prophages
Biota

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

Cite this

Joo, Jaewook ; Gunny, Michelle ; Cases, Marisa ; Hudson, Peter John ; Albert, Reka Z. ; Harvill, Eric Thomas. / Bacteriophage-mediated competition in Bordetella bacteria. In: Proceedings of the Royal Society B: Biological Sciences. 2006 ; Vol. 273, No. 1595. pp. 1843-1848.
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Bacteriophage-mediated competition in Bordetella bacteria. / Joo, Jaewook; Gunny, Michelle; Cases, Marisa; Hudson, Peter John; Albert, Reka Z.; Harvill, Eric Thomas.

In: Proceedings of the Royal Society B: Biological Sciences, Vol. 273, No. 1595, 01.01.2006, p. 1843-1848.

Research output: Contribution to journalArticle

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