Bacteriophages as tools for vaccine development.

G. F. Hatfull, L. Barsom, L. Chang, M. Donnelly-Wu, M. H. Lee, M. Levin, Chadd Nesbit, G. J. Sarkis

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

The construction of live recombinant bacterial vaccines requires a reasonably sophisticated genetic system for the introduction, stabilization and expression of foreign antigen genes. Bacteriophages offer a rich collection of tools that can be used for vaccine construction, including site-specific integration-proficient vectors, non-antibiotic selectable markers and signals for efficient transcription and translation of foreign genes. We describe the characterization of a temperate phage of the mycobacteria, mycobacteriophage L5, and application of these phage studies for the construction of recombinant BCG vaccines.

Original languageEnglish (US)
Pages (from-to)43-47
Number of pages5
JournalDevelopments in Biological Standardization
Volume82
StatePublished - Jan 1 1994

All Science Journal Classification (ASJC) codes

  • Immunology and Microbiology(all)
  • Drug Discovery
  • Public Health, Environmental and Occupational Health

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