Baroreflex modulation of muscle sympathetic nerve activity during cold pressor test in humans

Jian Cui, Thad E. Wilson, Craig G. Crandall

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The purpose of this project was to test the hypothesis that baroreceptor modulation of muscle sympathetic nerve activity (MSNA) and heart rate is altered during the cold pressor test. Ten subjects were exposed to a cold pressor test by immersing a hand in ice water for 3 min while arterial blood pressure, heart rate, and MSNA were recorded. During the second and third minute of the cold pressor test, blood pressure was lowered and then raised by intravenous bolus infusions of sodium nitroprusside and phenylephrine HCl, respectively. The slope of the relationship between MSNA and diastolic blood pressure was more negative (P < 0.005) during the cold pressor test (-244.9 ± 26.3 units·beat -1·mmHg -1) when compared with control conditions (-138.8 ± 18.6 units·beat -1·mmHg -1), whereas no significant change in the slope of the relationship between heart rate and systolic blood pressure was observed. These data suggest that baroreceptors remain capable of modulating MSNA and heart rate during a cold pressor test; however, the sensitivity of baroreflex modulation of MSNA is elevated without altering the sensitivity of baroreflex control of heart rate.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume282
Issue number5 51-5
StatePublished - Jun 29 2002

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Baroreflex
Heart Rate
Blood Pressure
Muscles
Pressoreceptors
Ice
Nitroprusside
Phenylephrine
Intravenous Infusions
Myocardium
Arterial Pressure
Hand
Water

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

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Baroreflex modulation of muscle sympathetic nerve activity during cold pressor test in humans. / Cui, Jian; Wilson, Thad E.; Crandall, Craig G.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 282, No. 5 51-5, 29.06.2002.

Research output: Contribution to journalArticle

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