Baseline predictors of visual acuity and retinal thickness outcomes in patients with retinal vein occlusion: Standard care versus corticosteroid for REtinal vein occlusion study report 10

Ingrid Scott, Paul C. Vanveldhuisen, Neal L. Oden, Michael S. Ip, Barbara A. Blodi, Mary Elizabeth Hartnett, Geoff Cohen

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Objective To investigate baseline factors associated with visual acuity and central retinal thickness outcomes in patients with macular edema secondary to retinal vein occlusion in the Standard Care versus COrticosteroid for REtinal Vein Occlusion (SCORE) Study. Design Two multicenter, randomized clinical trials: one evaluating participants with central retinal vein occlusion (CRVO) and one evaluating participants with branch retinal vein occlusion (BRVO). Participants Participants with follow-up data of 1 year or more, including 238 with CRVO and 367 with BRVO. Methods Visual acuity was measured by the electronic Early Treatment Diabetic Retinopathy Study (E-ETDRS) method, and central retinal thickness was measured by optical coherence tomography (OCT). Regression analysis related these outcomes to 20 baseline measures. Multiple P values were adjusted to control the false discovery rate. Main Outcome Measures Outcome measures of visual acuity letter score included absolute change from baseline, a gain of <15 from baseline, and a loss of <15 from baseline. Outcome measures of center point thickness included absolute change from baseline, a measurement of ≤250 μm, and a measurement of <500 μm. Outcomes were assessed at 1 and 2 years. Results For CRVO and BRVO, younger age was associated with improved visual acuity and central retinal thickness outcomes. For CRVO, triamcinolone treatment and less severe anatomic abnormalities of the retina (center point thickness and areas of retinal hemorrhage, thickening, and fluorescein leakage) were predictive of better visual acuity outcomes. For BRVO, no history of coronary artery disease was predictive of improved visual acuity outcomes. For center point thickness outcomes, shorter duration of macular edema was associated with improvement in both disease entities. For CRVO, higher baseline visual acuity letter score was predictive of favorable OCT outcomes. For BRVO, lower baseline visual acuity letter score, presence of dense macular hemorrhage, and no prior grid photocoagulation were predictive of favorable OCT outcomes. Conclusions Several factors were predictive of better visual acuity outcomes and more favorable OCT outcomes, including younger age and shorter duration of macular edema, respectively. These factors may assist clinicians in predicting disease course for patients with CRVO and BRVO. Financial Disclosure(s) Proprietary or commercial disclosure may be found after the references.

Original languageEnglish (US)
Pages (from-to)345-352
Number of pages8
JournalOphthalmology
Volume118
Issue number2
DOIs
StatePublished - Feb 1 2011

Fingerprint

Retinal Vein Occlusion
Visual Acuity
Adrenal Cortex Hormones
Retinal Vein
Optical Coherence Tomography
Macular Edema
Disclosure
Outcome Assessment (Health Care)
Retinal Hemorrhage
Triamcinolone
Light Coagulation
Diabetic Retinopathy
Fluorescein

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Scott, Ingrid ; Vanveldhuisen, Paul C. ; Oden, Neal L. ; Ip, Michael S. ; Blodi, Barbara A. ; Hartnett, Mary Elizabeth ; Cohen, Geoff. / Baseline predictors of visual acuity and retinal thickness outcomes in patients with retinal vein occlusion : Standard care versus corticosteroid for REtinal vein occlusion study report 10. In: Ophthalmology. 2011 ; Vol. 118, No. 2. pp. 345-352.
@article{a257c2c0d0c04306a43ab033f6d17702,
title = "Baseline predictors of visual acuity and retinal thickness outcomes in patients with retinal vein occlusion: Standard care versus corticosteroid for REtinal vein occlusion study report 10",
abstract = "Objective To investigate baseline factors associated with visual acuity and central retinal thickness outcomes in patients with macular edema secondary to retinal vein occlusion in the Standard Care versus COrticosteroid for REtinal Vein Occlusion (SCORE) Study. Design Two multicenter, randomized clinical trials: one evaluating participants with central retinal vein occlusion (CRVO) and one evaluating participants with branch retinal vein occlusion (BRVO). Participants Participants with follow-up data of 1 year or more, including 238 with CRVO and 367 with BRVO. Methods Visual acuity was measured by the electronic Early Treatment Diabetic Retinopathy Study (E-ETDRS) method, and central retinal thickness was measured by optical coherence tomography (OCT). Regression analysis related these outcomes to 20 baseline measures. Multiple P values were adjusted to control the false discovery rate. Main Outcome Measures Outcome measures of visual acuity letter score included absolute change from baseline, a gain of <15 from baseline, and a loss of <15 from baseline. Outcome measures of center point thickness included absolute change from baseline, a measurement of ≤250 μm, and a measurement of <500 μm. Outcomes were assessed at 1 and 2 years. Results For CRVO and BRVO, younger age was associated with improved visual acuity and central retinal thickness outcomes. For CRVO, triamcinolone treatment and less severe anatomic abnormalities of the retina (center point thickness and areas of retinal hemorrhage, thickening, and fluorescein leakage) were predictive of better visual acuity outcomes. For BRVO, no history of coronary artery disease was predictive of improved visual acuity outcomes. For center point thickness outcomes, shorter duration of macular edema was associated with improvement in both disease entities. For CRVO, higher baseline visual acuity letter score was predictive of favorable OCT outcomes. For BRVO, lower baseline visual acuity letter score, presence of dense macular hemorrhage, and no prior grid photocoagulation were predictive of favorable OCT outcomes. Conclusions Several factors were predictive of better visual acuity outcomes and more favorable OCT outcomes, including younger age and shorter duration of macular edema, respectively. These factors may assist clinicians in predicting disease course for patients with CRVO and BRVO. Financial Disclosure(s) Proprietary or commercial disclosure may be found after the references.",
author = "Ingrid Scott and Vanveldhuisen, {Paul C.} and Oden, {Neal L.} and Ip, {Michael S.} and Blodi, {Barbara A.} and Hartnett, {Mary Elizabeth} and Geoff Cohen",
year = "2011",
month = "2",
day = "1",
doi = "10.1016/j.ophtha.2010.06.034",
language = "English (US)",
volume = "118",
pages = "345--352",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "2",

}

Baseline predictors of visual acuity and retinal thickness outcomes in patients with retinal vein occlusion : Standard care versus corticosteroid for REtinal vein occlusion study report 10. / Scott, Ingrid; Vanveldhuisen, Paul C.; Oden, Neal L.; Ip, Michael S.; Blodi, Barbara A.; Hartnett, Mary Elizabeth; Cohen, Geoff.

In: Ophthalmology, Vol. 118, No. 2, 01.02.2011, p. 345-352.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Baseline predictors of visual acuity and retinal thickness outcomes in patients with retinal vein occlusion

T2 - Standard care versus corticosteroid for REtinal vein occlusion study report 10

AU - Scott, Ingrid

AU - Vanveldhuisen, Paul C.

AU - Oden, Neal L.

AU - Ip, Michael S.

AU - Blodi, Barbara A.

AU - Hartnett, Mary Elizabeth

AU - Cohen, Geoff

PY - 2011/2/1

Y1 - 2011/2/1

N2 - Objective To investigate baseline factors associated with visual acuity and central retinal thickness outcomes in patients with macular edema secondary to retinal vein occlusion in the Standard Care versus COrticosteroid for REtinal Vein Occlusion (SCORE) Study. Design Two multicenter, randomized clinical trials: one evaluating participants with central retinal vein occlusion (CRVO) and one evaluating participants with branch retinal vein occlusion (BRVO). Participants Participants with follow-up data of 1 year or more, including 238 with CRVO and 367 with BRVO. Methods Visual acuity was measured by the electronic Early Treatment Diabetic Retinopathy Study (E-ETDRS) method, and central retinal thickness was measured by optical coherence tomography (OCT). Regression analysis related these outcomes to 20 baseline measures. Multiple P values were adjusted to control the false discovery rate. Main Outcome Measures Outcome measures of visual acuity letter score included absolute change from baseline, a gain of <15 from baseline, and a loss of <15 from baseline. Outcome measures of center point thickness included absolute change from baseline, a measurement of ≤250 μm, and a measurement of <500 μm. Outcomes were assessed at 1 and 2 years. Results For CRVO and BRVO, younger age was associated with improved visual acuity and central retinal thickness outcomes. For CRVO, triamcinolone treatment and less severe anatomic abnormalities of the retina (center point thickness and areas of retinal hemorrhage, thickening, and fluorescein leakage) were predictive of better visual acuity outcomes. For BRVO, no history of coronary artery disease was predictive of improved visual acuity outcomes. For center point thickness outcomes, shorter duration of macular edema was associated with improvement in both disease entities. For CRVO, higher baseline visual acuity letter score was predictive of favorable OCT outcomes. For BRVO, lower baseline visual acuity letter score, presence of dense macular hemorrhage, and no prior grid photocoagulation were predictive of favorable OCT outcomes. Conclusions Several factors were predictive of better visual acuity outcomes and more favorable OCT outcomes, including younger age and shorter duration of macular edema, respectively. These factors may assist clinicians in predicting disease course for patients with CRVO and BRVO. Financial Disclosure(s) Proprietary or commercial disclosure may be found after the references.

AB - Objective To investigate baseline factors associated with visual acuity and central retinal thickness outcomes in patients with macular edema secondary to retinal vein occlusion in the Standard Care versus COrticosteroid for REtinal Vein Occlusion (SCORE) Study. Design Two multicenter, randomized clinical trials: one evaluating participants with central retinal vein occlusion (CRVO) and one evaluating participants with branch retinal vein occlusion (BRVO). Participants Participants with follow-up data of 1 year or more, including 238 with CRVO and 367 with BRVO. Methods Visual acuity was measured by the electronic Early Treatment Diabetic Retinopathy Study (E-ETDRS) method, and central retinal thickness was measured by optical coherence tomography (OCT). Regression analysis related these outcomes to 20 baseline measures. Multiple P values were adjusted to control the false discovery rate. Main Outcome Measures Outcome measures of visual acuity letter score included absolute change from baseline, a gain of <15 from baseline, and a loss of <15 from baseline. Outcome measures of center point thickness included absolute change from baseline, a measurement of ≤250 μm, and a measurement of <500 μm. Outcomes were assessed at 1 and 2 years. Results For CRVO and BRVO, younger age was associated with improved visual acuity and central retinal thickness outcomes. For CRVO, triamcinolone treatment and less severe anatomic abnormalities of the retina (center point thickness and areas of retinal hemorrhage, thickening, and fluorescein leakage) were predictive of better visual acuity outcomes. For BRVO, no history of coronary artery disease was predictive of improved visual acuity outcomes. For center point thickness outcomes, shorter duration of macular edema was associated with improvement in both disease entities. For CRVO, higher baseline visual acuity letter score was predictive of favorable OCT outcomes. For BRVO, lower baseline visual acuity letter score, presence of dense macular hemorrhage, and no prior grid photocoagulation were predictive of favorable OCT outcomes. Conclusions Several factors were predictive of better visual acuity outcomes and more favorable OCT outcomes, including younger age and shorter duration of macular edema, respectively. These factors may assist clinicians in predicting disease course for patients with CRVO and BRVO. Financial Disclosure(s) Proprietary or commercial disclosure may be found after the references.

UR - http://www.scopus.com/inward/record.url?scp=79551548893&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79551548893&partnerID=8YFLogxK

U2 - 10.1016/j.ophtha.2010.06.034

DO - 10.1016/j.ophtha.2010.06.034

M3 - Article

C2 - 20926135

AN - SCOPUS:79551548893

VL - 118

SP - 345

EP - 352

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

IS - 2

ER -