Battle for the bulge: Directing small molecules to DNA and RNA defects

Philip C. Bevilacqua

doi:10.1016/S1074-5521(02)00197-7

Battle for the bulge: Directing small molecules to DNA and RNA defects

Philip C. Bevilacqua

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Small molecules were tailored to specifically bind bulged DNA by complementing the geometry and nucleotide size of the bulge site. The prospect of generating small molecules that influence the secondary structure of DNA and RNA holds great promise for clinical applications.

Original language	English (US)
Pages (from-to)	854-855
Number of pages	2
Journal	Chemistry and Biology
Volume	9
Issue number	8
DOIs	https://doi.org/10.1016/S1074-5521(02)00197-7
State	Published - Aug 2002

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Clinical Biochemistry

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10.1016/S1074-5521(02)00197-7

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title = "Battle for the bulge: Directing small molecules to DNA and RNA defects",

abstract = "Small molecules were tailored to specifically bind bulged DNA by complementing the geometry and nucleotide size of the bulge site. The prospect of generating small molecules that influence the secondary structure of DNA and RNA holds great promise for clinical applications.",

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year = "2002",

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