Abstract
Small molecules were tailored to specifically bind bulged DNA by complementing the geometry and nucleotide size of the bulge site. The prospect of generating small molecules that influence the secondary structure of DNA and RNA holds great promise for clinical applications.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 854-855 |
| Number of pages | 2 |
| Journal | Chemistry and Biology |
| Volume | 9 |
| Issue number | 8 |
| DOIs | |
| State | Published - Jan 1 2002 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmacology
- Drug Discovery
- Clinical Biochemistry
Cite this
}
Battle for the bulge : Directing small molecules to DNA and RNA defects. / Bevilacqua, Philip C.
In: Chemistry and Biology, Vol. 9, No. 8, 01.01.2002, p. 854-855.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Battle for the bulge
T2 - Directing small molecules to DNA and RNA defects
AU - Bevilacqua, Philip C.
PY - 2002/1/1
Y1 - 2002/1/1
N2 - Small molecules were tailored to specifically bind bulged DNA by complementing the geometry and nucleotide size of the bulge site. The prospect of generating small molecules that influence the secondary structure of DNA and RNA holds great promise for clinical applications.
AB - Small molecules were tailored to specifically bind bulged DNA by complementing the geometry and nucleotide size of the bulge site. The prospect of generating small molecules that influence the secondary structure of DNA and RNA holds great promise for clinical applications.
UR - http://www.scopus.com/inward/record.url?scp=0036669395&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036669395&partnerID=8YFLogxK
U2 - 10.1016/S1074-5521(02)00197-7
DO - 10.1016/S1074-5521(02)00197-7
M3 - Review article
C2 - 12204683
AN - SCOPUS:0036669395
VL - 9
SP - 854
EP - 855
JO - Cell Chemical Biology
JF - Cell Chemical Biology
SN - 2451-9448
IS - 8
ER -