Battle for the bulge: Directing small molecules to DNA and RNA defects

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Small molecules were tailored to specifically bind bulged DNA by complementing the geometry and nucleotide size of the bulge site. The prospect of generating small molecules that influence the secondary structure of DNA and RNA holds great promise for clinical applications.

Original languageEnglish (US)
Pages (from-to)854-855
Number of pages2
JournalChemistry and Biology
Volume9
Issue number8
DOIs
StatePublished - Jan 1 2002

Fingerprint

RNA
Defects
Molecules
DNA
Nucleotides
Geometry

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

@article{388834331df546349e8be576f2d89b0d,
title = "Battle for the bulge: Directing small molecules to DNA and RNA defects",
abstract = "Small molecules were tailored to specifically bind bulged DNA by complementing the geometry and nucleotide size of the bulge site. The prospect of generating small molecules that influence the secondary structure of DNA and RNA holds great promise for clinical applications.",
author = "Bevilacqua, {Philip C.}",
year = "2002",
month = "1",
day = "1",
doi = "10.1016/S1074-5521(02)00197-7",
language = "English (US)",
volume = "9",
pages = "854--855",
journal = "Cell Chemical Biology",
issn = "2451-9448",
publisher = "Elsevier Inc.",
number = "8",

}

Battle for the bulge : Directing small molecules to DNA and RNA defects. / Bevilacqua, Philip C.

In: Chemistry and Biology, Vol. 9, No. 8, 01.01.2002, p. 854-855.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Battle for the bulge

T2 - Directing small molecules to DNA and RNA defects

AU - Bevilacqua, Philip C.

PY - 2002/1/1

Y1 - 2002/1/1

N2 - Small molecules were tailored to specifically bind bulged DNA by complementing the geometry and nucleotide size of the bulge site. The prospect of generating small molecules that influence the secondary structure of DNA and RNA holds great promise for clinical applications.

AB - Small molecules were tailored to specifically bind bulged DNA by complementing the geometry and nucleotide size of the bulge site. The prospect of generating small molecules that influence the secondary structure of DNA and RNA holds great promise for clinical applications.

UR - http://www.scopus.com/inward/record.url?scp=0036669395&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036669395&partnerID=8YFLogxK

U2 - 10.1016/S1074-5521(02)00197-7

DO - 10.1016/S1074-5521(02)00197-7

M3 - Review article

C2 - 12204683

AN - SCOPUS:0036669395

VL - 9

SP - 854

EP - 855

JO - Cell Chemical Biology

JF - Cell Chemical Biology

SN - 2451-9448

IS - 8

ER -