Baz, Par-6 and aPKC are not required for axon or dendrite specification in Drosophila

Melissa M. Rolls, Chris Q. Doe

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Par-3/Baz, Par-6, and aPKC are evolutionarily conserved regulators of cell polarity, and overexpression experiments implicate them as axon determinants in vertebrate hippocampal neurons. Here we examined their mutant and overexpression phenotypes in Drosophila melanogaster. We found that mutants neurons had normal axon and dendrite morphology and remodeled axons correctly in metamorphosis, and that overexpression did not affect axon or dendrite specification. Baz/Par-6/aPKC are therefore not essential for axon specification in Drosophila.

Original languageEnglish (US)
Pages (from-to)1293-1295
Number of pages3
JournalNature Neuroscience
Volume7
Issue number12
DOIs
StatePublished - Dec 1 2004

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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