Behavioral and Electrophysiological Indices of Negative Affect Predict Cocaine Self-Administration

Robert A. Wheeler, Robert C. Twining, Joshua L. Jones, Jennifer M. Slater, Patricia S. Grigson, Regina M M. Carelli

Research output: Contribution to journalArticlepeer-review

118 Scopus citations

Abstract

The motivation to seek cocaine comes in part from a dysregulation of reward processing manifested in dysphoria, or affective withdrawal. Learning is a critical aspect of drug abuse; however, it remains unclear whether drug-associated cues can elicit the emotional withdrawal symptoms that promote cocaine use. Here we report that a cocaine-associated taste cue elicited a conditioned aversive state that was behaviorally and neurophysiologically quantifiable and predicted subsequent cocaine self-administration behavior. Specifically, brief intraoral infusions of a cocaine-predictive flavored saccharin solution elicited aversive orofacial responses that predicted early-session cocaine taking in rats. The expression of aversive taste reactivity also was associated with a shift in the predominant pattern of electrophysiological activity of nucleus accumbens (NAc) neurons from inhibitory to excitatory. The dynamic nature of this conditioned switch in affect and the neural code reveals a mechanism by which cues may exert control over drug self-administration.

Original languageEnglish (US)
Pages (from-to)774-785
Number of pages12
JournalNeuron
Volume57
Issue number5
DOIs
StatePublished - Mar 13 2008

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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