Behavioral genetic contributions to the study of addiction-related amphetamine effects

Tamara J. Phillips, Helen M. Kamens, Jeanna M. Wheeler

    Research output: Contribution to journalReview article

    34 Citations (Scopus)

    Abstract

    Amphetamines, including methamphetamine, pose a significant cost to society due to significant numbers of amphetamine-abusing individuals who suffer major health-related consequences. In addition, methamphetamine use is associated with heightened rates of violent and property-related crimes. The current paper reviews the existing literature addressing genetic differences in mice that impact behavioral responses thought to be relevant to the abuse of amphetamine and amphetamine-like drugs. Summarized are studies that used inbred strains, selected lines, single-gene knockouts and transgenics, and quantitative trait locus (QTL) mapping populations. Acute sensitivity, neuroadaptive responses, rewarding and conditioned effects are among those reviewed. Some gene mapping work has been accomplished, and although no amphetamine-related complex trait genes have been definitively identified, translational work leading from results in the mouse to studies performed in humans is beginning to emerge. The majority of genetic investigations have utilized single-gene knockout mice and have concentrated on dopamine- and glutamate-related genes. Genes that code for cell support and signaling molecules are also well-represented. There is a large behavioral genetic literature on responsiveness to amphetamines, but a considerably smaller literature focused on genes that influence the development and acceleration of amphetamine use, withdrawal, relapse, and behavioral toxicity. Also missing are genetic investigations into the effects of amphetamines on social behaviors. This information might help to identify at-risk individuals and in the future to develop treatments that take advantage of individualized genetic information.

    Original languageEnglish (US)
    Pages (from-to)707-759
    Number of pages53
    JournalNeuroscience and Biobehavioral Reviews
    Volume32
    Issue number4
    DOIs
    StatePublished - Jan 21 2008

    Fingerprint

    Amphetamine-Related Disorders
    Behavioral Genetics
    Amphetamine
    Amphetamines
    Gene Knockout Techniques
    Methamphetamine
    Genes
    Social Behavior
    Chromosome Mapping
    Quantitative Trait Loci
    Crime
    Knockout Mice
    Glutamic Acid
    Dopamine
    Costs and Cost Analysis
    Recurrence
    Health
    Pharmaceutical Preparations
    Population

    All Science Journal Classification (ASJC) codes

    • Neuropsychology and Physiological Psychology
    • Cognitive Neuroscience
    • Behavioral Neuroscience

    Cite this

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    Behavioral genetic contributions to the study of addiction-related amphetamine effects. / Phillips, Tamara J.; Kamens, Helen M.; Wheeler, Jeanna M.

    In: Neuroscience and Biobehavioral Reviews, Vol. 32, No. 4, 21.01.2008, p. 707-759.

    Research output: Contribution to journalReview article

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