Behavioral inhibition and glucocorticoid dynamics in a rodent model

Sonia Angele Cavigelli, Michele M. Stine, Colleen Kovacsics, Akilah Jefferson, Mai N. Diep, Catherine E. Barrett

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Behavioral inhibition (i.e. avoidance of unfamiliar) has been linked to significant differences in stress physiology and health. Developing an animal model of this common temperament provides a means to experimentally study the development and physiology of this trait as it relates to stress-related health processes. To elaborate such an animal model, we studied individual rat responses to two novel situations that mimic behavioral inhibition tests for humans (one non-social and one social). We measured individual consistency of behavioral responses across tests and time, and examined the relationship between behavior and glucocorticoid levels in outbred Sprague-Dawley male rats. Individuals were consistent in their behavioral responses to the same novel environment over time, but not in their responses across two different environments (i.e. non-social vs. social). A third of males were slow to approach novelty in both arenas (INHIBITED) and another third were fast to approach in both arenas (NON-INHIBITED). Behavioral inhibition was relatively stable across time and was associated with increased glucocorticoid production at baseline and in response to novelty but not during a post-novelty recovery period. Glucocorticoid levels were more closely related to their responses to the social novel arena than the non-social arena. Thus, behavioral inhibition is associated with acute and basal glucocorticoid over production and social inhibition is a more important predictor of adrenal activity than non-social inhibition. These preliminary observations provide strong support for an animal model of human behavioral inhibition and identify specific aspect of glucocorticoid production dynamics to examine in behaviorally inhibited children.

Original languageEnglish (US)
Pages (from-to)897-905
Number of pages9
JournalPhysiology and Behavior
Volume92
Issue number5
DOIs
StatePublished - Dec 5 2007

Fingerprint

Glucocorticoids
Rodentia
Animal Models
Temperament
Health
Inhibition (Psychology)
Sprague Dawley Rats

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Cite this

Cavigelli, S. A., Stine, M. M., Kovacsics, C., Jefferson, A., Diep, M. N., & Barrett, C. E. (2007). Behavioral inhibition and glucocorticoid dynamics in a rodent model. Physiology and Behavior, 92(5), 897-905. https://doi.org/10.1016/j.physbeh.2007.06.016
Cavigelli, Sonia Angele ; Stine, Michele M. ; Kovacsics, Colleen ; Jefferson, Akilah ; Diep, Mai N. ; Barrett, Catherine E. / Behavioral inhibition and glucocorticoid dynamics in a rodent model. In: Physiology and Behavior. 2007 ; Vol. 92, No. 5. pp. 897-905.
@article{05ee2d8a390b450686504b702d4a7539,
title = "Behavioral inhibition and glucocorticoid dynamics in a rodent model",
abstract = "Behavioral inhibition (i.e. avoidance of unfamiliar) has been linked to significant differences in stress physiology and health. Developing an animal model of this common temperament provides a means to experimentally study the development and physiology of this trait as it relates to stress-related health processes. To elaborate such an animal model, we studied individual rat responses to two novel situations that mimic behavioral inhibition tests for humans (one non-social and one social). We measured individual consistency of behavioral responses across tests and time, and examined the relationship between behavior and glucocorticoid levels in outbred Sprague-Dawley male rats. Individuals were consistent in their behavioral responses to the same novel environment over time, but not in their responses across two different environments (i.e. non-social vs. social). A third of males were slow to approach novelty in both arenas (INHIBITED) and another third were fast to approach in both arenas (NON-INHIBITED). Behavioral inhibition was relatively stable across time and was associated with increased glucocorticoid production at baseline and in response to novelty but not during a post-novelty recovery period. Glucocorticoid levels were more closely related to their responses to the social novel arena than the non-social arena. Thus, behavioral inhibition is associated with acute and basal glucocorticoid over production and social inhibition is a more important predictor of adrenal activity than non-social inhibition. These preliminary observations provide strong support for an animal model of human behavioral inhibition and identify specific aspect of glucocorticoid production dynamics to examine in behaviorally inhibited children.",
author = "Cavigelli, {Sonia Angele} and Stine, {Michele M.} and Colleen Kovacsics and Akilah Jefferson and Diep, {Mai N.} and Barrett, {Catherine E.}",
year = "2007",
month = "12",
day = "5",
doi = "10.1016/j.physbeh.2007.06.016",
language = "English (US)",
volume = "92",
pages = "897--905",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "5",

}

Cavigelli, SA, Stine, MM, Kovacsics, C, Jefferson, A, Diep, MN & Barrett, CE 2007, 'Behavioral inhibition and glucocorticoid dynamics in a rodent model', Physiology and Behavior, vol. 92, no. 5, pp. 897-905. https://doi.org/10.1016/j.physbeh.2007.06.016

Behavioral inhibition and glucocorticoid dynamics in a rodent model. / Cavigelli, Sonia Angele; Stine, Michele M.; Kovacsics, Colleen; Jefferson, Akilah; Diep, Mai N.; Barrett, Catherine E.

In: Physiology and Behavior, Vol. 92, No. 5, 05.12.2007, p. 897-905.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Behavioral inhibition and glucocorticoid dynamics in a rodent model

AU - Cavigelli, Sonia Angele

AU - Stine, Michele M.

AU - Kovacsics, Colleen

AU - Jefferson, Akilah

AU - Diep, Mai N.

AU - Barrett, Catherine E.

PY - 2007/12/5

Y1 - 2007/12/5

N2 - Behavioral inhibition (i.e. avoidance of unfamiliar) has been linked to significant differences in stress physiology and health. Developing an animal model of this common temperament provides a means to experimentally study the development and physiology of this trait as it relates to stress-related health processes. To elaborate such an animal model, we studied individual rat responses to two novel situations that mimic behavioral inhibition tests for humans (one non-social and one social). We measured individual consistency of behavioral responses across tests and time, and examined the relationship between behavior and glucocorticoid levels in outbred Sprague-Dawley male rats. Individuals were consistent in their behavioral responses to the same novel environment over time, but not in their responses across two different environments (i.e. non-social vs. social). A third of males were slow to approach novelty in both arenas (INHIBITED) and another third were fast to approach in both arenas (NON-INHIBITED). Behavioral inhibition was relatively stable across time and was associated with increased glucocorticoid production at baseline and in response to novelty but not during a post-novelty recovery period. Glucocorticoid levels were more closely related to their responses to the social novel arena than the non-social arena. Thus, behavioral inhibition is associated with acute and basal glucocorticoid over production and social inhibition is a more important predictor of adrenal activity than non-social inhibition. These preliminary observations provide strong support for an animal model of human behavioral inhibition and identify specific aspect of glucocorticoid production dynamics to examine in behaviorally inhibited children.

AB - Behavioral inhibition (i.e. avoidance of unfamiliar) has been linked to significant differences in stress physiology and health. Developing an animal model of this common temperament provides a means to experimentally study the development and physiology of this trait as it relates to stress-related health processes. To elaborate such an animal model, we studied individual rat responses to two novel situations that mimic behavioral inhibition tests for humans (one non-social and one social). We measured individual consistency of behavioral responses across tests and time, and examined the relationship between behavior and glucocorticoid levels in outbred Sprague-Dawley male rats. Individuals were consistent in their behavioral responses to the same novel environment over time, but not in their responses across two different environments (i.e. non-social vs. social). A third of males were slow to approach novelty in both arenas (INHIBITED) and another third were fast to approach in both arenas (NON-INHIBITED). Behavioral inhibition was relatively stable across time and was associated with increased glucocorticoid production at baseline and in response to novelty but not during a post-novelty recovery period. Glucocorticoid levels were more closely related to their responses to the social novel arena than the non-social arena. Thus, behavioral inhibition is associated with acute and basal glucocorticoid over production and social inhibition is a more important predictor of adrenal activity than non-social inhibition. These preliminary observations provide strong support for an animal model of human behavioral inhibition and identify specific aspect of glucocorticoid production dynamics to examine in behaviorally inhibited children.

UR - http://www.scopus.com/inward/record.url?scp=36048949613&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36048949613&partnerID=8YFLogxK

U2 - 10.1016/j.physbeh.2007.06.016

DO - 10.1016/j.physbeh.2007.06.016

M3 - Article

C2 - 17673266

AN - SCOPUS:36048949613

VL - 92

SP - 897

EP - 905

JO - Physiology and Behavior

JF - Physiology and Behavior

SN - 0031-9384

IS - 5

ER -