Behavioral stress responses in premenopausal and postmenopausal women and the effects of estrogen

Steven R. Lindheim, Richard Legro, Leslie Bernstein, Frank Z. Stanczyk, Marcela A. Vijod, Steven C. Presser, Rogerio A. Lobo

Research output: Contribution to journalArticle

184 Citations (Scopus)

Abstract

OBJECTIVE: Our purpose was to determine the pattern of reactivity to stress in premenopausal and postmenopausal women and to assess the effects of estrogen. STUDY DESIGN: A behavioral stress test was given to premenopausal (n = 13) and postmenopausal women (n = 36). Biophysical and neuroendocrine responses were measured during and on completion of the stress test. The postmenopausal women were then randomized to placebo or transdermal estradiol treatment for 6 weeks, at which time another behavioral stress test was given. RESULTS: Stress reactivity to math and speech tasks elicited significantly greater systolic blood pressure responses in postmenopausal women compared with premenopausal women (p < 0.05). On retesting, significant biophysical responses that were present during the initial stress testing were still present (p < 0.05) in the placebo group but were blunted with estrogen treatment. Plasma corticotropin, cortisol, and rostenedione, and norepinephrine increased during testing to a similar degree in premenopausal and postmenopausal women; this response was maintained after placebo treatment. Postmenopausal women treated with estrogen had blunted responses. CONCLUSION: Significant differences in responses to psychologic stress exist in premenopausal and postmenopausal women. The lack of adaptation may account in part for the increased risk of cardiovascular disease in postmenopausal women. Estrogen appears to blunt the stress-induced response.

Original languageEnglish (US)
Pages (from-to)1831-1836
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume167
Issue number6
DOIs
StatePublished - Jan 1 1992

Fingerprint

Estrogens
Exercise Test
Placebos
Blood Pressure
Psychological Stress
Adrenocorticotropic Hormone
Hydrocortisone
Estradiol
Norepinephrine
Cardiovascular Diseases
Therapeutics

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Lindheim, Steven R. ; Legro, Richard ; Bernstein, Leslie ; Stanczyk, Frank Z. ; Vijod, Marcela A. ; Presser, Steven C. ; Lobo, Rogerio A. / Behavioral stress responses in premenopausal and postmenopausal women and the effects of estrogen. In: American Journal of Obstetrics and Gynecology. 1992 ; Vol. 167, No. 6. pp. 1831-1836.
@article{8bdb2e8bcb304852990b40ea47ee0b94,
title = "Behavioral stress responses in premenopausal and postmenopausal women and the effects of estrogen",
abstract = "OBJECTIVE: Our purpose was to determine the pattern of reactivity to stress in premenopausal and postmenopausal women and to assess the effects of estrogen. STUDY DESIGN: A behavioral stress test was given to premenopausal (n = 13) and postmenopausal women (n = 36). Biophysical and neuroendocrine responses were measured during and on completion of the stress test. The postmenopausal women were then randomized to placebo or transdermal estradiol treatment for 6 weeks, at which time another behavioral stress test was given. RESULTS: Stress reactivity to math and speech tasks elicited significantly greater systolic blood pressure responses in postmenopausal women compared with premenopausal women (p < 0.05). On retesting, significant biophysical responses that were present during the initial stress testing were still present (p < 0.05) in the placebo group but were blunted with estrogen treatment. Plasma corticotropin, cortisol, and rostenedione, and norepinephrine increased during testing to a similar degree in premenopausal and postmenopausal women; this response was maintained after placebo treatment. Postmenopausal women treated with estrogen had blunted responses. CONCLUSION: Significant differences in responses to psychologic stress exist in premenopausal and postmenopausal women. The lack of adaptation may account in part for the increased risk of cardiovascular disease in postmenopausal women. Estrogen appears to blunt the stress-induced response.",
author = "Lindheim, {Steven R.} and Richard Legro and Leslie Bernstein and Stanczyk, {Frank Z.} and Vijod, {Marcela A.} and Presser, {Steven C.} and Lobo, {Rogerio A.}",
year = "1992",
month = "1",
day = "1",
doi = "10.1016/0002-9378(92)91783-7",
language = "English (US)",
volume = "167",
pages = "1831--1836",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "6",

}

Behavioral stress responses in premenopausal and postmenopausal women and the effects of estrogen. / Lindheim, Steven R.; Legro, Richard; Bernstein, Leslie; Stanczyk, Frank Z.; Vijod, Marcela A.; Presser, Steven C.; Lobo, Rogerio A.

In: American Journal of Obstetrics and Gynecology, Vol. 167, No. 6, 01.01.1992, p. 1831-1836.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Behavioral stress responses in premenopausal and postmenopausal women and the effects of estrogen

AU - Lindheim, Steven R.

AU - Legro, Richard

AU - Bernstein, Leslie

AU - Stanczyk, Frank Z.

AU - Vijod, Marcela A.

AU - Presser, Steven C.

AU - Lobo, Rogerio A.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - OBJECTIVE: Our purpose was to determine the pattern of reactivity to stress in premenopausal and postmenopausal women and to assess the effects of estrogen. STUDY DESIGN: A behavioral stress test was given to premenopausal (n = 13) and postmenopausal women (n = 36). Biophysical and neuroendocrine responses were measured during and on completion of the stress test. The postmenopausal women were then randomized to placebo or transdermal estradiol treatment for 6 weeks, at which time another behavioral stress test was given. RESULTS: Stress reactivity to math and speech tasks elicited significantly greater systolic blood pressure responses in postmenopausal women compared with premenopausal women (p < 0.05). On retesting, significant biophysical responses that were present during the initial stress testing were still present (p < 0.05) in the placebo group but were blunted with estrogen treatment. Plasma corticotropin, cortisol, and rostenedione, and norepinephrine increased during testing to a similar degree in premenopausal and postmenopausal women; this response was maintained after placebo treatment. Postmenopausal women treated with estrogen had blunted responses. CONCLUSION: Significant differences in responses to psychologic stress exist in premenopausal and postmenopausal women. The lack of adaptation may account in part for the increased risk of cardiovascular disease in postmenopausal women. Estrogen appears to blunt the stress-induced response.

AB - OBJECTIVE: Our purpose was to determine the pattern of reactivity to stress in premenopausal and postmenopausal women and to assess the effects of estrogen. STUDY DESIGN: A behavioral stress test was given to premenopausal (n = 13) and postmenopausal women (n = 36). Biophysical and neuroendocrine responses were measured during and on completion of the stress test. The postmenopausal women were then randomized to placebo or transdermal estradiol treatment for 6 weeks, at which time another behavioral stress test was given. RESULTS: Stress reactivity to math and speech tasks elicited significantly greater systolic blood pressure responses in postmenopausal women compared with premenopausal women (p < 0.05). On retesting, significant biophysical responses that were present during the initial stress testing were still present (p < 0.05) in the placebo group but were blunted with estrogen treatment. Plasma corticotropin, cortisol, and rostenedione, and norepinephrine increased during testing to a similar degree in premenopausal and postmenopausal women; this response was maintained after placebo treatment. Postmenopausal women treated with estrogen had blunted responses. CONCLUSION: Significant differences in responses to psychologic stress exist in premenopausal and postmenopausal women. The lack of adaptation may account in part for the increased risk of cardiovascular disease in postmenopausal women. Estrogen appears to blunt the stress-induced response.

UR - http://www.scopus.com/inward/record.url?scp=0026621087&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026621087&partnerID=8YFLogxK

U2 - 10.1016/0002-9378(92)91783-7

DO - 10.1016/0002-9378(92)91783-7

M3 - Article

C2 - 1471706

AN - SCOPUS:0026621087

VL - 167

SP - 1831

EP - 1836

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 6

ER -