Benefits of influenza vaccination on the associations between ambient air pollution and allergic respiratory diseases in children and adolescents: New insights from the Seven Northeastern Cities study in China

Kangkang Liu, Shanshan Li, Zhengmin (Min) Qian, Shyamali C. Dharmage, Michael S. Bloom, Joachim Heinrich, Bin Jalaludin, Iana Markevych, Lidia Morawska, Luke D. Knibbs, Leslie Hinyard, Hong Xian, Shan Liu, Shao Lin, Ari Leskinen, Mika Komppula, Pasi Jalava, Marjut Roponen, Li Wen Hu, Xiao Wen ZengWenbiao Hu, Gongbo Chen, Bo Yi Yang, Yuming Guo, Guang Hui Dong

Research output: Contribution to journalArticle

Abstract

Background: Little information exists on interaction effects between air pollution and influenza vaccination on allergic respiratory diseases. We conducted a large population-based study to evaluate the interaction effects between influenza vaccination and long-term exposure to ambient air pollution on allergic respiratory diseases in children and adolescents. Methods: A cross-sectional study was investigated during 2012–2013 in 94 schools from Seven Northeastern Cities (SNEC) in China. Questionnaires surveys were obtained from 56 137 children and adolescents aged 2–17 years. Influenza vaccination was defined as receipt of the influenza vaccine. We estimated air pollutants exposure [nitrogen dioxide (NO2) and particulate matter with aerodynamic diameters ≤1 μm (PM1), ≤2.5 μm (PM2.5) and ≤10 μm (PM10)] using machine learning methods. We employed two-level generalized linear mix effects model to examine interactive effects between influenza vaccination and air pollution exposure on allergic respiratory diseases (asthma, asthma-related symptoms and allergic rhinitis), after controlling for important covariates. Results: We found statistically significant interactions between influenza vaccination and air pollutants on allergic respiratory diseases and related symptoms (doctor-diagnosed asthma, current wheeze, wheeze, persistent phlegm and allergic rhinitis). The adjusted ORs for doctor-diagnosed asthma, current wheeze and allergic rhinitis among the unvaccinated group per interquartile range (IQR) increase in PM1 and PM2.5 were significantly higher than the corresponding ORs among the vaccinated group [For PM1, doctor-diagnosed asthma: OR: 1.89 (95%CI: 1.57–2.27) vs 1.65 (95%CI: 1.36–2.00); current wheeze: OR: 1.50 (95%CI: 1.22–1.85) vs 1.10 (95%CI: 0.89–1.37); allergic rhinitis: OR: 1.38 (95%CI: 1.15–1.66) vs 1.21 (95%CI: 1.00–1.46). For PM2.5, doctor-diagnosed asthma: OR: 1.81 (95%CI: 1.52–2.14) vs 1.57 (95%CI: 1.32–1.88); current wheeze: OR: 1.46 (95%CI: 1.21–1.76) vs 1.11 (95%CI: 0.91–1.35); allergic rhinitis: OR: 1.35 (95%CI: 1.14–1.60) vs 1.19 (95%CI: 1.00–1.42)]. The similar patterns were observed for wheeze and persistent phlegm. The corresponding p values for interactions were less than 0.05, respectively. We assessed the risks of PM1-related and PM2.5-related current wheeze were decreased by 26.67% (95%CI: 1.04%–45.66%) and 23.97% (95%CI: 0.21%–42.08%) respectively, which was attributable to influenza vaccination (both p for efficiency <0.05). Conclusions: Influenza vaccination may play an important role in mitigating the detrimental effects of long-term exposure to ambient air pollution on childhood allergic respiratory diseases. Policy targeted at increasing influenza vaccination may yield co-benefits in terms of reduced allergic respiratory diseases.

Original languageEnglish (US)
Article number113434
JournalEnvironmental Pollution
Volume256
DOIs
StatePublished - Jan 2020

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Pulmonary diseases
Air Pollution
Air pollution
Human Influenza
China
Vaccination
Asthma
Air Pollutants
Nitrogen Dioxide
Vaccines
Particulate Matter
Influenza Vaccines
Air
Learning systems
Aerodynamics
Nitrogen
Cross-Sectional Studies
Allergic Rhinitis

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

Liu, Kangkang ; Li, Shanshan ; Qian, Zhengmin (Min) ; Dharmage, Shyamali C. ; Bloom, Michael S. ; Heinrich, Joachim ; Jalaludin, Bin ; Markevych, Iana ; Morawska, Lidia ; Knibbs, Luke D. ; Hinyard, Leslie ; Xian, Hong ; Liu, Shan ; Lin, Shao ; Leskinen, Ari ; Komppula, Mika ; Jalava, Pasi ; Roponen, Marjut ; Hu, Li Wen ; Zeng, Xiao Wen ; Hu, Wenbiao ; Chen, Gongbo ; Yang, Bo Yi ; Guo, Yuming ; Dong, Guang Hui. / Benefits of influenza vaccination on the associations between ambient air pollution and allergic respiratory diseases in children and adolescents : New insights from the Seven Northeastern Cities study in China. In: Environmental Pollution. 2020 ; Vol. 256.
@article{31fb059ad7ad4d90883bf85a86af0efc,
title = "Benefits of influenza vaccination on the associations between ambient air pollution and allergic respiratory diseases in children and adolescents: New insights from the Seven Northeastern Cities study in China",
abstract = "Background: Little information exists on interaction effects between air pollution and influenza vaccination on allergic respiratory diseases. We conducted a large population-based study to evaluate the interaction effects between influenza vaccination and long-term exposure to ambient air pollution on allergic respiratory diseases in children and adolescents. Methods: A cross-sectional study was investigated during 2012–2013 in 94 schools from Seven Northeastern Cities (SNEC) in China. Questionnaires surveys were obtained from 56 137 children and adolescents aged 2–17 years. Influenza vaccination was defined as receipt of the influenza vaccine. We estimated air pollutants exposure [nitrogen dioxide (NO2) and particulate matter with aerodynamic diameters ≤1 μm (PM1), ≤2.5 μm (PM2.5) and ≤10 μm (PM10)] using machine learning methods. We employed two-level generalized linear mix effects model to examine interactive effects between influenza vaccination and air pollution exposure on allergic respiratory diseases (asthma, asthma-related symptoms and allergic rhinitis), after controlling for important covariates. Results: We found statistically significant interactions between influenza vaccination and air pollutants on allergic respiratory diseases and related symptoms (doctor-diagnosed asthma, current wheeze, wheeze, persistent phlegm and allergic rhinitis). The adjusted ORs for doctor-diagnosed asthma, current wheeze and allergic rhinitis among the unvaccinated group per interquartile range (IQR) increase in PM1 and PM2.5 were significantly higher than the corresponding ORs among the vaccinated group [For PM1, doctor-diagnosed asthma: OR: 1.89 (95{\%}CI: 1.57–2.27) vs 1.65 (95{\%}CI: 1.36–2.00); current wheeze: OR: 1.50 (95{\%}CI: 1.22–1.85) vs 1.10 (95{\%}CI: 0.89–1.37); allergic rhinitis: OR: 1.38 (95{\%}CI: 1.15–1.66) vs 1.21 (95{\%}CI: 1.00–1.46). For PM2.5, doctor-diagnosed asthma: OR: 1.81 (95{\%}CI: 1.52–2.14) vs 1.57 (95{\%}CI: 1.32–1.88); current wheeze: OR: 1.46 (95{\%}CI: 1.21–1.76) vs 1.11 (95{\%}CI: 0.91–1.35); allergic rhinitis: OR: 1.35 (95{\%}CI: 1.14–1.60) vs 1.19 (95{\%}CI: 1.00–1.42)]. The similar patterns were observed for wheeze and persistent phlegm. The corresponding p values for interactions were less than 0.05, respectively. We assessed the risks of PM1-related and PM2.5-related current wheeze were decreased by 26.67{\%} (95{\%}CI: 1.04{\%}–45.66{\%}) and 23.97{\%} (95{\%}CI: 0.21{\%}–42.08{\%}) respectively, which was attributable to influenza vaccination (both p for efficiency <0.05). Conclusions: Influenza vaccination may play an important role in mitigating the detrimental effects of long-term exposure to ambient air pollution on childhood allergic respiratory diseases. Policy targeted at increasing influenza vaccination may yield co-benefits in terms of reduced allergic respiratory diseases.",
author = "Kangkang Liu and Shanshan Li and Qian, {Zhengmin (Min)} and Dharmage, {Shyamali C.} and Bloom, {Michael S.} and Joachim Heinrich and Bin Jalaludin and Iana Markevych and Lidia Morawska and Knibbs, {Luke D.} and Leslie Hinyard and Hong Xian and Shan Liu and Shao Lin and Ari Leskinen and Mika Komppula and Pasi Jalava and Marjut Roponen and Hu, {Li Wen} and Zeng, {Xiao Wen} and Wenbiao Hu and Gongbo Chen and Yang, {Bo Yi} and Yuming Guo and Dong, {Guang Hui}",
year = "2020",
month = "1",
doi = "10.1016/j.envpol.2019.113434",
language = "English (US)",
volume = "256",
journal = "Environmental Pollution",
issn = "0269-7491",
publisher = "Elsevier Limited",

}

Liu, K, Li, S, Qian, ZM, Dharmage, SC, Bloom, MS, Heinrich, J, Jalaludin, B, Markevych, I, Morawska, L, Knibbs, LD, Hinyard, L, Xian, H, Liu, S, Lin, S, Leskinen, A, Komppula, M, Jalava, P, Roponen, M, Hu, LW, Zeng, XW, Hu, W, Chen, G, Yang, BY, Guo, Y & Dong, GH 2020, 'Benefits of influenza vaccination on the associations between ambient air pollution and allergic respiratory diseases in children and adolescents: New insights from the Seven Northeastern Cities study in China', Environmental Pollution, vol. 256, 113434. https://doi.org/10.1016/j.envpol.2019.113434

Benefits of influenza vaccination on the associations between ambient air pollution and allergic respiratory diseases in children and adolescents : New insights from the Seven Northeastern Cities study in China. / Liu, Kangkang; Li, Shanshan; Qian, Zhengmin (Min); Dharmage, Shyamali C.; Bloom, Michael S.; Heinrich, Joachim; Jalaludin, Bin; Markevych, Iana; Morawska, Lidia; Knibbs, Luke D.; Hinyard, Leslie; Xian, Hong; Liu, Shan; Lin, Shao; Leskinen, Ari; Komppula, Mika; Jalava, Pasi; Roponen, Marjut; Hu, Li Wen; Zeng, Xiao Wen; Hu, Wenbiao; Chen, Gongbo; Yang, Bo Yi; Guo, Yuming; Dong, Guang Hui.

In: Environmental Pollution, Vol. 256, 113434, 01.2020.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Benefits of influenza vaccination on the associations between ambient air pollution and allergic respiratory diseases in children and adolescents

T2 - New insights from the Seven Northeastern Cities study in China

AU - Liu, Kangkang

AU - Li, Shanshan

AU - Qian, Zhengmin (Min)

AU - Dharmage, Shyamali C.

AU - Bloom, Michael S.

AU - Heinrich, Joachim

AU - Jalaludin, Bin

AU - Markevych, Iana

AU - Morawska, Lidia

AU - Knibbs, Luke D.

AU - Hinyard, Leslie

AU - Xian, Hong

AU - Liu, Shan

AU - Lin, Shao

AU - Leskinen, Ari

AU - Komppula, Mika

AU - Jalava, Pasi

AU - Roponen, Marjut

AU - Hu, Li Wen

AU - Zeng, Xiao Wen

AU - Hu, Wenbiao

AU - Chen, Gongbo

AU - Yang, Bo Yi

AU - Guo, Yuming

AU - Dong, Guang Hui

PY - 2020/1

Y1 - 2020/1

N2 - Background: Little information exists on interaction effects between air pollution and influenza vaccination on allergic respiratory diseases. We conducted a large population-based study to evaluate the interaction effects between influenza vaccination and long-term exposure to ambient air pollution on allergic respiratory diseases in children and adolescents. Methods: A cross-sectional study was investigated during 2012–2013 in 94 schools from Seven Northeastern Cities (SNEC) in China. Questionnaires surveys were obtained from 56 137 children and adolescents aged 2–17 years. Influenza vaccination was defined as receipt of the influenza vaccine. We estimated air pollutants exposure [nitrogen dioxide (NO2) and particulate matter with aerodynamic diameters ≤1 μm (PM1), ≤2.5 μm (PM2.5) and ≤10 μm (PM10)] using machine learning methods. We employed two-level generalized linear mix effects model to examine interactive effects between influenza vaccination and air pollution exposure on allergic respiratory diseases (asthma, asthma-related symptoms and allergic rhinitis), after controlling for important covariates. Results: We found statistically significant interactions between influenza vaccination and air pollutants on allergic respiratory diseases and related symptoms (doctor-diagnosed asthma, current wheeze, wheeze, persistent phlegm and allergic rhinitis). The adjusted ORs for doctor-diagnosed asthma, current wheeze and allergic rhinitis among the unvaccinated group per interquartile range (IQR) increase in PM1 and PM2.5 were significantly higher than the corresponding ORs among the vaccinated group [For PM1, doctor-diagnosed asthma: OR: 1.89 (95%CI: 1.57–2.27) vs 1.65 (95%CI: 1.36–2.00); current wheeze: OR: 1.50 (95%CI: 1.22–1.85) vs 1.10 (95%CI: 0.89–1.37); allergic rhinitis: OR: 1.38 (95%CI: 1.15–1.66) vs 1.21 (95%CI: 1.00–1.46). For PM2.5, doctor-diagnosed asthma: OR: 1.81 (95%CI: 1.52–2.14) vs 1.57 (95%CI: 1.32–1.88); current wheeze: OR: 1.46 (95%CI: 1.21–1.76) vs 1.11 (95%CI: 0.91–1.35); allergic rhinitis: OR: 1.35 (95%CI: 1.14–1.60) vs 1.19 (95%CI: 1.00–1.42)]. The similar patterns were observed for wheeze and persistent phlegm. The corresponding p values for interactions were less than 0.05, respectively. We assessed the risks of PM1-related and PM2.5-related current wheeze were decreased by 26.67% (95%CI: 1.04%–45.66%) and 23.97% (95%CI: 0.21%–42.08%) respectively, which was attributable to influenza vaccination (both p for efficiency <0.05). Conclusions: Influenza vaccination may play an important role in mitigating the detrimental effects of long-term exposure to ambient air pollution on childhood allergic respiratory diseases. Policy targeted at increasing influenza vaccination may yield co-benefits in terms of reduced allergic respiratory diseases.

AB - Background: Little information exists on interaction effects between air pollution and influenza vaccination on allergic respiratory diseases. We conducted a large population-based study to evaluate the interaction effects between influenza vaccination and long-term exposure to ambient air pollution on allergic respiratory diseases in children and adolescents. Methods: A cross-sectional study was investigated during 2012–2013 in 94 schools from Seven Northeastern Cities (SNEC) in China. Questionnaires surveys were obtained from 56 137 children and adolescents aged 2–17 years. Influenza vaccination was defined as receipt of the influenza vaccine. We estimated air pollutants exposure [nitrogen dioxide (NO2) and particulate matter with aerodynamic diameters ≤1 μm (PM1), ≤2.5 μm (PM2.5) and ≤10 μm (PM10)] using machine learning methods. We employed two-level generalized linear mix effects model to examine interactive effects between influenza vaccination and air pollution exposure on allergic respiratory diseases (asthma, asthma-related symptoms and allergic rhinitis), after controlling for important covariates. Results: We found statistically significant interactions between influenza vaccination and air pollutants on allergic respiratory diseases and related symptoms (doctor-diagnosed asthma, current wheeze, wheeze, persistent phlegm and allergic rhinitis). The adjusted ORs for doctor-diagnosed asthma, current wheeze and allergic rhinitis among the unvaccinated group per interquartile range (IQR) increase in PM1 and PM2.5 were significantly higher than the corresponding ORs among the vaccinated group [For PM1, doctor-diagnosed asthma: OR: 1.89 (95%CI: 1.57–2.27) vs 1.65 (95%CI: 1.36–2.00); current wheeze: OR: 1.50 (95%CI: 1.22–1.85) vs 1.10 (95%CI: 0.89–1.37); allergic rhinitis: OR: 1.38 (95%CI: 1.15–1.66) vs 1.21 (95%CI: 1.00–1.46). For PM2.5, doctor-diagnosed asthma: OR: 1.81 (95%CI: 1.52–2.14) vs 1.57 (95%CI: 1.32–1.88); current wheeze: OR: 1.46 (95%CI: 1.21–1.76) vs 1.11 (95%CI: 0.91–1.35); allergic rhinitis: OR: 1.35 (95%CI: 1.14–1.60) vs 1.19 (95%CI: 1.00–1.42)]. The similar patterns were observed for wheeze and persistent phlegm. The corresponding p values for interactions were less than 0.05, respectively. We assessed the risks of PM1-related and PM2.5-related current wheeze were decreased by 26.67% (95%CI: 1.04%–45.66%) and 23.97% (95%CI: 0.21%–42.08%) respectively, which was attributable to influenza vaccination (both p for efficiency <0.05). Conclusions: Influenza vaccination may play an important role in mitigating the detrimental effects of long-term exposure to ambient air pollution on childhood allergic respiratory diseases. Policy targeted at increasing influenza vaccination may yield co-benefits in terms of reduced allergic respiratory diseases.

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U2 - 10.1016/j.envpol.2019.113434

DO - 10.1016/j.envpol.2019.113434

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C2 - 31672350

AN - SCOPUS:85074429367

VL - 256

JO - Environmental Pollution

JF - Environmental Pollution

SN - 0269-7491

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