Beta-lactam antibiotics

From antibiosis to resistance and bacteriology

Kok Fai Kong, Lisa Schneper, Kalai Mathee

Research output: Contribution to journalReview article

127 Citations (Scopus)

Abstract

Kong K-F, Schneper L, Mathee K. Beta-lactam antibiotics: from antibiosis to resistance and bacteriology. APMIS 2010; 118: 1-36. This review focuses on the era of antibiosis that led to a better understanding of bacterial morphology, in particular the cell wall component peptidoglycan. This is an effort to take readers on a tour de force from the concept of antibiosis, to the serendipity of antibiotics, evolution of beta-lactam development, and the molecular biology of antibiotic resistance. These areas of research have culminated in a deeper understanding of microbiology, particularly in the area of bacterial cell wall synthesis and recycling. In spite of this knowledge, which has enabled design of new even more effective therapeutics to combat bacterial infection and has provided new research tools, antibiotic resistance remains a worldwide health care problem.

Original languageEnglish (US)
Pages (from-to)1-36
Number of pages36
JournalAPMIS
Volume118
Issue number1
DOIs
StatePublished - Jan 1 2010

Fingerprint

Antibiosis
Bacteriology
beta-Lactams
Microbial Drug Resistance
Anti-Bacterial Agents
Cell Wall
Peptidoglycan
Recycling
Cellular Structures
Microbiology
Research
Bacterial Infections
Molecular Biology
Delivery of Health Care
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Immunology and Allergy
  • Microbiology (medical)

Cite this

Kong, Kok Fai ; Schneper, Lisa ; Mathee, Kalai. / Beta-lactam antibiotics : From antibiosis to resistance and bacteriology. In: APMIS. 2010 ; Vol. 118, No. 1. pp. 1-36.
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Beta-lactam antibiotics : From antibiosis to resistance and bacteriology. / Kong, Kok Fai; Schneper, Lisa; Mathee, Kalai.

In: APMIS, Vol. 118, No. 1, 01.01.2010, p. 1-36.

Research output: Contribution to journalReview article

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