Between form and function: The complexity of genome folding

A. Marieke Oudelaar, Lars L.P. Hanssen, Ross C. Hardison, Mira T. Kassouf, Jim R. Hughes, Douglas R. Higgs

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


It has been known for over a century that chromatin is not randomly distributed within the nucleus. However, the question of how DNA is folded and the influence of such folding on nuclear processes remain topics of intensive current research. A longstanding, unanswered question is whether nuclear organization is simply a reflection of nuclear processes such as transcription and replication, or whether chromatin is folded by independent mechanisms and this per se encodes function? Evidence is emerging that both may be true. Here, using the a-globin gene cluster as an illustrative model, we provide an overview of the most recent insights into the layers of genome organization across different scales and how this relates to gene activity.

Original languageEnglish (US)
Pages (from-to)R208-R215
JournalHuman molecular genetics
Issue numberR2
StatePublished - Oct 1 2017

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Genetics(clinical)


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