Beyond Purple Hearts: A Colorful Approach to Isolate Distinct Heart Cells from Human iPSCs

Lauren N. Randolph, Xiaojun Lian

Research output: Contribution to journalShort survey

Abstract

In this issue of Cell Stem Cell, Zhang et al. (2019) describe a double-reporter iPSC line based on the expression of key cardiac transcription factors, TBX5 and NKX2.5, that delineates cardiac lineage specification in vitro and enables isolation of relatively pure chamber-specific cardiomyocytes, which are critical for drug screening, tissue engineering, and disease modeling.

Original languageEnglish (US)
JournalCell Stem Cell
DOIs
StatePublished - Jan 1 2019

Fingerprint

Preclinical Drug Evaluations
Tissue Engineering
Cardiac Myocytes
Transcription Factors
Stem Cells
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Genetics
  • Cell Biology

Cite this

@article{1b381bcfd45e40d7919e308cc8eeeb33,
title = "Beyond Purple Hearts: A Colorful Approach to Isolate Distinct Heart Cells from Human iPSCs",
abstract = "In this issue of Cell Stem Cell, Zhang et al. (2019) describe a double-reporter iPSC line based on the expression of key cardiac transcription factors, TBX5 and NKX2.5, that delineates cardiac lineage specification in vitro and enables isolation of relatively pure chamber-specific cardiomyocytes, which are critical for drug screening, tissue engineering, and disease modeling.",
author = "Randolph, {Lauren N.} and Xiaojun Lian",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.stem.2019.04.003",
language = "English (US)",
journal = "Cell Stem Cell",
issn = "1934-5909",
publisher = "Cell Press",

}

Beyond Purple Hearts : A Colorful Approach to Isolate Distinct Heart Cells from Human iPSCs. / Randolph, Lauren N.; Lian, Xiaojun.

In: Cell Stem Cell, 01.01.2019.

Research output: Contribution to journalShort survey

TY - JOUR

T1 - Beyond Purple Hearts

T2 - A Colorful Approach to Isolate Distinct Heart Cells from Human iPSCs

AU - Randolph, Lauren N.

AU - Lian, Xiaojun

PY - 2019/1/1

Y1 - 2019/1/1

N2 - In this issue of Cell Stem Cell, Zhang et al. (2019) describe a double-reporter iPSC line based on the expression of key cardiac transcription factors, TBX5 and NKX2.5, that delineates cardiac lineage specification in vitro and enables isolation of relatively pure chamber-specific cardiomyocytes, which are critical for drug screening, tissue engineering, and disease modeling.

AB - In this issue of Cell Stem Cell, Zhang et al. (2019) describe a double-reporter iPSC line based on the expression of key cardiac transcription factors, TBX5 and NKX2.5, that delineates cardiac lineage specification in vitro and enables isolation of relatively pure chamber-specific cardiomyocytes, which are critical for drug screening, tissue engineering, and disease modeling.

UR - http://www.scopus.com/inward/record.url?scp=85063934656&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063934656&partnerID=8YFLogxK

U2 - 10.1016/j.stem.2019.04.003

DO - 10.1016/j.stem.2019.04.003

M3 - Short survey

C2 - 31051127

AN - SCOPUS:85063934656

JO - Cell Stem Cell

JF - Cell Stem Cell

SN - 1934-5909

ER -