In this issue of Cell Stem Cell, Zhang et al. (2019)describe a double-reporter iPSC line based on the expression of key cardiac transcription factors, TBX5 and NKX2.5, that delineates cardiac lineage specification in vitro and enables isolation of relatively pure chamber-specific cardiomyocytes, which are critical for drug screening, tissue engineering, and disease modeling.
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Cell Biology