Beyond replication: division and segregation of mitochondrial DNA in kinetoplastids

Research output: Contribution to journalReview article

30 Scopus citations

Abstract

The mitochondrial genome of kinetoplastids, called kinetoplast DNA (kDNA) is a complex structure that must be faithfully duplicated exactly once per cell cycle. Despite many years of thorough investigation into the kDNA replication mechanism, many of the molecular details of the later stages of the process, particularly kDNA division and segregation, remain mysterious. In addition, perturbation of several cellular activities, some only indirectly related to kDNA, can lead to asymmetric kDNA division and other segregation defects. This review will examine unifying features and possible explanations for these phenotypes in the context of current models for kDNA division and segregation.

Original languageEnglish (US)
Pages (from-to)53-60
Number of pages8
JournalMolecular and biochemical parasitology
Volume196
Issue number1
DOIs
StatePublished - Aug 1 2014

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Molecular Biology

Fingerprint Dive into the research topics of 'Beyond replication: division and segregation of mitochondrial DNA in kinetoplastids'. Together they form a unique fingerprint.

  • Cite this