Beyond ribosome rescue: tmRNA and co-translational processes

Christopher S. Hayes, Kenneth C. Keiler

Research output: Contribution to journalReview article

62 Citations (Scopus)

Abstract

tmRNA is a unique bi-functional RNA that acts as both a tRNA and an mRNA to enter stalled ribosomes and direct the addition of a peptide tag to the C terminus of nascent polypeptides. Despite a reasonably clear understanding of tmRNA activity, the reason for its absolute conservation throughout the eubacteria is unknown. Although tmRNA plays many physiological roles in different bacterial systems, recent studies suggest a general role for trans-translation in monitoring protein folding and perhaps other co-translational processes. This review will focus on these new hypotheses and the data that support them.

Original languageEnglish (US)
Pages (from-to)413-419
Number of pages7
JournalFEBS Letters
Volume584
Issue number2
DOIs
StatePublished - Jan 21 2010

Fingerprint

Ribosomes
Protein folding
Peptides
Protein Folding
Transfer RNA
Conservation
RNA
Bacteria
Messenger RNA
Monitoring
tmRNA

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Hayes, Christopher S. ; Keiler, Kenneth C. / Beyond ribosome rescue : tmRNA and co-translational processes. In: FEBS Letters. 2010 ; Vol. 584, No. 2. pp. 413-419.
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Beyond ribosome rescue : tmRNA and co-translational processes. / Hayes, Christopher S.; Keiler, Kenneth C.

In: FEBS Letters, Vol. 584, No. 2, 21.01.2010, p. 413-419.

Research output: Contribution to journalReview article

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