Beyond ribosome rescue: tmRNA and co-translational processes

Christopher S. Hayes, Kenneth C. Keiler

Research output: Contribution to journalReview articlepeer-review

64 Scopus citations

Abstract

tmRNA is a unique bi-functional RNA that acts as both a tRNA and an mRNA to enter stalled ribosomes and direct the addition of a peptide tag to the C terminus of nascent polypeptides. Despite a reasonably clear understanding of tmRNA activity, the reason for its absolute conservation throughout the eubacteria is unknown. Although tmRNA plays many physiological roles in different bacterial systems, recent studies suggest a general role for trans-translation in monitoring protein folding and perhaps other co-translational processes. This review will focus on these new hypotheses and the data that support them.

Original languageEnglish (US)
Pages (from-to)413-419
Number of pages7
JournalFEBS Letters
Volume584
Issue number2
DOIs
StatePublished - Jan 21 2010

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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