Bicuculline attenuates the MLR-induced suppression of dorsal horn neurons receiving group III afferent input

Alexandr M. Degtyarenko, Marc Kaufman

Research output: Contribution to journalArticle

2 Scopus citations


In decerebrate cats, we found that iontophoretic application of bicuculline, a GABAA receptor antagonist, attenuated the mesencephalic locomotor region-induced suppression of dorsal horn neurons responding to group III afferent input from the hindlimb. Our findings raise the possibility that GABA release onto dorsal horn neurons in the spinal cord may play an important role in the attenuation of the exercise pressor reflex by central command during exercise.

Original languageEnglish (US)
Pages (from-to)109-113
Number of pages5
JournalBrain research
Issue number1-2
Publication statusPublished - May 10 2002


All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this