Bicuculline-induced alterations in neuronal responses to controlled tactile stimuli in the second somatosensory cortex of the cat: A microiontophoretic study

Kevin Alloway, H. Burton

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19 Citations (Scopus)

Abstract

Single-neuron activity (n = 29) was recorded from the second somatosensory cortex of cats, and the effect of glutamate, γ-amino-butyric acid (GABA), and bicuculline methiodide (BMI) on spontaneous and stimulus-induced responses were analyzed. Iontophoresis of glutamate produced dose-dependent increases in spontaneous activity, whereas GABA suppressed both spontaneous and glutamate-induced activity. Neuronal responses elicited by cutaneous stimuli were also inhibited by GABA in a dose-dependent fashion; current levels needed to produce at least a 25-50% decrease in stimulus-evoked activity ranged from 5 to 100 nA, with a mean of about 45 nA. Iontophoresis of BMI (10-75 nA) effectively antagonized GABA-induced inhibition of stimulus-evoked responses without altering spontaneous activity. Furthermore, BMI increased the magnitude of responses produced by ramp stimuli and caused a several-fold increase in receptive field size. For neurons responsive to sinusoidal stimulation, BMI caused an increase in the frequency-following probability at preferred frequencies, but failed to alter the response to nonpreferred frequencies. These results suggest that GABA-ergic circuits may limit response magnitude but not the submodality properties of somatosensory cortical neurons.

Original languageEnglish (US)
Pages (from-to)197-211
Number of pages15
JournalSomatosensory Research
Volume3
Issue number3
StatePublished - 1985

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Somatosensory Cortex
Bicuculline
Touch
Glutamic Acid
Butyric Acid
Cats
Iontophoresis
Neurons
Architectural Accessibility
Skin
bicuculline methiodide

All Science Journal Classification (ASJC) codes

  • Physiology
  • Neuroscience(all)

Cite this

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title = "Bicuculline-induced alterations in neuronal responses to controlled tactile stimuli in the second somatosensory cortex of the cat: A microiontophoretic study",
abstract = "Single-neuron activity (n = 29) was recorded from the second somatosensory cortex of cats, and the effect of glutamate, γ-amino-butyric acid (GABA), and bicuculline methiodide (BMI) on spontaneous and stimulus-induced responses were analyzed. Iontophoresis of glutamate produced dose-dependent increases in spontaneous activity, whereas GABA suppressed both spontaneous and glutamate-induced activity. Neuronal responses elicited by cutaneous stimuli were also inhibited by GABA in a dose-dependent fashion; current levels needed to produce at least a 25-50{\%} decrease in stimulus-evoked activity ranged from 5 to 100 nA, with a mean of about 45 nA. Iontophoresis of BMI (10-75 nA) effectively antagonized GABA-induced inhibition of stimulus-evoked responses without altering spontaneous activity. Furthermore, BMI increased the magnitude of responses produced by ramp stimuli and caused a several-fold increase in receptive field size. For neurons responsive to sinusoidal stimulation, BMI caused an increase in the frequency-following probability at preferred frequencies, but failed to alter the response to nonpreferred frequencies. These results suggest that GABA-ergic circuits may limit response magnitude but not the submodality properties of somatosensory cortical neurons.",
author = "Kevin Alloway and H. Burton",
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journal = "Somatosensory Research",
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AU - Burton, H.

PY - 1985

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N2 - Single-neuron activity (n = 29) was recorded from the second somatosensory cortex of cats, and the effect of glutamate, γ-amino-butyric acid (GABA), and bicuculline methiodide (BMI) on spontaneous and stimulus-induced responses were analyzed. Iontophoresis of glutamate produced dose-dependent increases in spontaneous activity, whereas GABA suppressed both spontaneous and glutamate-induced activity. Neuronal responses elicited by cutaneous stimuli were also inhibited by GABA in a dose-dependent fashion; current levels needed to produce at least a 25-50% decrease in stimulus-evoked activity ranged from 5 to 100 nA, with a mean of about 45 nA. Iontophoresis of BMI (10-75 nA) effectively antagonized GABA-induced inhibition of stimulus-evoked responses without altering spontaneous activity. Furthermore, BMI increased the magnitude of responses produced by ramp stimuli and caused a several-fold increase in receptive field size. For neurons responsive to sinusoidal stimulation, BMI caused an increase in the frequency-following probability at preferred frequencies, but failed to alter the response to nonpreferred frequencies. These results suggest that GABA-ergic circuits may limit response magnitude but not the submodality properties of somatosensory cortical neurons.

AB - Single-neuron activity (n = 29) was recorded from the second somatosensory cortex of cats, and the effect of glutamate, γ-amino-butyric acid (GABA), and bicuculline methiodide (BMI) on spontaneous and stimulus-induced responses were analyzed. Iontophoresis of glutamate produced dose-dependent increases in spontaneous activity, whereas GABA suppressed both spontaneous and glutamate-induced activity. Neuronal responses elicited by cutaneous stimuli were also inhibited by GABA in a dose-dependent fashion; current levels needed to produce at least a 25-50% decrease in stimulus-evoked activity ranged from 5 to 100 nA, with a mean of about 45 nA. Iontophoresis of BMI (10-75 nA) effectively antagonized GABA-induced inhibition of stimulus-evoked responses without altering spontaneous activity. Furthermore, BMI increased the magnitude of responses produced by ramp stimuli and caused a several-fold increase in receptive field size. For neurons responsive to sinusoidal stimulation, BMI caused an increase in the frequency-following probability at preferred frequencies, but failed to alter the response to nonpreferred frequencies. These results suggest that GABA-ergic circuits may limit response magnitude but not the submodality properties of somatosensory cortical neurons.

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