Binding of human alpha-interferon in the brain tissue membranes of rat

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Abstract

The receptor binding characteristics of human lymphoblastoid alpha- interferon (IFN) to human Daudi cell line was compared with its binding to membrane homogenates derived from various regions of rat brain. Rat brain membranes bound specifically a detectable amount of I-125 alpha interferon revealing the receptor affinity constant (Kd) of 3.9 - 4.2 x 10-10 M and the Bmax was 0.9 - 1.7 fmoles/mg wet weight tissue depending on the analyzed brain region (the highest Bmax was obtained in the membranes from the hypothalamus region, the lowest one from the spinal cord membranes).

Original languageEnglish (US)
Pages (from-to)117-120
Number of pages4
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume75
Issue number1
Publication statusPublished - Jan 1 1992

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All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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