Bioassay for carcinogenicity of 3,2′-dimethyl-4-nitrosobiphenyl, O-nitrosotoluene, nitrosobenzene and the corresponding amines in Syrian golden hamsters

Stephen S. Hecht, Karam El-Bayoumy, Abraham Rivenson, Emerich S. Fiala

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

3,2′-Dimethyl-4-aminobiphenyl and 3,2′-dimethyl-4-nitrosobiphenyl were administered by subcutaneous injection in peanut oil to 2 groups of 15 male and 15 female Syrian golden hamsters. The total dose of each compound was 5.6 mmol/kg. In the group treated with 3,2′-dimethyl-4-aminobiphenyl, 24 animals had bladder tumors. In the group treated with 3,2′-dimethyl-4-nitrosobiphenyl 25 animals had subcutaneous tumors and 2 had bladder tumors. These results indicate that 3,2′-dimethyl-4-nitrosobiphenyl is a potent locally acting carcinogen. Total doses of 99 mmol/kg of aniline, o-toluidine, nitrosobenzene, or o-nitrosotoluene administered by subcutaneous injection failed to induce tumors.

Original languageEnglish (US)
Pages (from-to)349-354
Number of pages6
JournalCancer Letters
Volume20
Issue number3
DOIs
StatePublished - Oct 1983

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Mesocricetus
Biological Assay
Amines
2-toluidine
Subcutaneous Injections
Urinary Bladder Neoplasms
Carcinogens
Neoplasms
3,2'-dimethyl-4-nitrosobiphenyl
nitrosobenzene
2',3-dimethyl-4-aminobiphenyl

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

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title = "Bioassay for carcinogenicity of 3,2′-dimethyl-4-nitrosobiphenyl, O-nitrosotoluene, nitrosobenzene and the corresponding amines in Syrian golden hamsters",
abstract = "3,2′-Dimethyl-4-aminobiphenyl and 3,2′-dimethyl-4-nitrosobiphenyl were administered by subcutaneous injection in peanut oil to 2 groups of 15 male and 15 female Syrian golden hamsters. The total dose of each compound was 5.6 mmol/kg. In the group treated with 3,2′-dimethyl-4-aminobiphenyl, 24 animals had bladder tumors. In the group treated with 3,2′-dimethyl-4-nitrosobiphenyl 25 animals had subcutaneous tumors and 2 had bladder tumors. These results indicate that 3,2′-dimethyl-4-nitrosobiphenyl is a potent locally acting carcinogen. Total doses of 99 mmol/kg of aniline, o-toluidine, nitrosobenzene, or o-nitrosotoluene administered by subcutaneous injection failed to induce tumors.",
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Bioassay for carcinogenicity of 3,2′-dimethyl-4-nitrosobiphenyl, O-nitrosotoluene, nitrosobenzene and the corresponding amines in Syrian golden hamsters. / Hecht, Stephen S.; El-Bayoumy, Karam; Rivenson, Abraham; Fiala, Emerich S.

In: Cancer Letters, Vol. 20, No. 3, 10.1983, p. 349-354.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Bioassay for carcinogenicity of 3,2′-dimethyl-4-nitrosobiphenyl, O-nitrosotoluene, nitrosobenzene and the corresponding amines in Syrian golden hamsters

AU - Hecht, Stephen S.

AU - El-Bayoumy, Karam

AU - Rivenson, Abraham

AU - Fiala, Emerich S.

PY - 1983/10

Y1 - 1983/10

N2 - 3,2′-Dimethyl-4-aminobiphenyl and 3,2′-dimethyl-4-nitrosobiphenyl were administered by subcutaneous injection in peanut oil to 2 groups of 15 male and 15 female Syrian golden hamsters. The total dose of each compound was 5.6 mmol/kg. In the group treated with 3,2′-dimethyl-4-aminobiphenyl, 24 animals had bladder tumors. In the group treated with 3,2′-dimethyl-4-nitrosobiphenyl 25 animals had subcutaneous tumors and 2 had bladder tumors. These results indicate that 3,2′-dimethyl-4-nitrosobiphenyl is a potent locally acting carcinogen. Total doses of 99 mmol/kg of aniline, o-toluidine, nitrosobenzene, or o-nitrosotoluene administered by subcutaneous injection failed to induce tumors.

AB - 3,2′-Dimethyl-4-aminobiphenyl and 3,2′-dimethyl-4-nitrosobiphenyl were administered by subcutaneous injection in peanut oil to 2 groups of 15 male and 15 female Syrian golden hamsters. The total dose of each compound was 5.6 mmol/kg. In the group treated with 3,2′-dimethyl-4-aminobiphenyl, 24 animals had bladder tumors. In the group treated with 3,2′-dimethyl-4-nitrosobiphenyl 25 animals had subcutaneous tumors and 2 had bladder tumors. These results indicate that 3,2′-dimethyl-4-nitrosobiphenyl is a potent locally acting carcinogen. Total doses of 99 mmol/kg of aniline, o-toluidine, nitrosobenzene, or o-nitrosotoluene administered by subcutaneous injection failed to induce tumors.

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