Bioassay for carcinogenicity of 3,2′-dimethyl-4-nitrosobiphenyl, O-nitrosotoluene, nitrosobenzene and the corresponding amines in Syrian golden hamsters

Stephen S. Hecht, Karam El-Bayoumy, Abraham Rivenson, Emerich S. Fiala

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

3,2′-Dimethyl-4-aminobiphenyl and 3,2′-dimethyl-4-nitrosobiphenyl were administered by subcutaneous injection in peanut oil to 2 groups of 15 male and 15 female Syrian golden hamsters. The total dose of each compound was 5.6 mmol/kg. In the group treated with 3,2′-dimethyl-4-aminobiphenyl, 24 animals had bladder tumors. In the group treated with 3,2′-dimethyl-4-nitrosobiphenyl 25 animals had subcutaneous tumors and 2 had bladder tumors. These results indicate that 3,2′-dimethyl-4-nitrosobiphenyl is a potent locally acting carcinogen. Total doses of 99 mmol/kg of aniline, o-toluidine, nitrosobenzene, or o-nitrosotoluene administered by subcutaneous injection failed to induce tumors.

Original languageEnglish (US)
Pages (from-to)349-354
Number of pages6
JournalCancer Letters
Volume20
Issue number3
DOIs
StatePublished - Oct 1983

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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