Bioavailability and stability issues in understanding the cancer preventive effects of tea polyphenols

Shengmin Sang, Joshua D. Lambert, Chung S. Yang

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

The cancer preventive activities of tea (Camellia sinensis) have received a great deal of attention from researchers and the general public. The inhibition of carcinogenesis by tea and tea polyphenols has been demonstrated in different animal models of skin, lung, intestinal and other cancer types by many investigators. Numerous mechanisms for the cancer preventive activity have been proposed based on studies of human cancer cell lines without considering the bioavailability of tea polyphenols. The proposed inhibition of mitogen activated protein (MAP) kinases, aberrant arachidonic acid metabolism, nuclear factor κB (NFκB) and activator protein 1 (AP-1) mediated transcription, growth factor-mediated signaling, and other activities could lead to the inhibition of tumor cell growth or induction of apoptosis as well as the inhibition of angiogenesis. In many cases, however, the concentrations of tea polyphenols required to observe these biological effects in vitro exceed the concentrations achievable in blood and tissues by 10- to 100-fold. In addition, in vitro studies are complicated by the fact that tea polyphenols are not stable and reactive oxygen species are generated under most cell culture conditions. It is not clear whether these reactions occur in vivo. From the bioavailability and stability viewpoints, we herein discuss the relevance of in vitro observations to the mechanisms of the cancer preventive activities of tea polyphenols in vivo.

Original languageEnglish (US)
Pages (from-to)2256-2265
Number of pages10
JournalJournal of the science of food and agriculture
Volume86
Issue number14
DOIs
StatePublished - Nov 1 2006

Fingerprint

Polyphenols
Tea
tea
Biological Availability
bioavailability
polyphenols
neoplasms
Neoplasms
Research Personnel
Camellia sinensis
Intestinal Neoplasms
Transcription Factor AP-1
angiogenesis
Mitogen-Activated Protein Kinases
arachidonic acid
mitogen-activated protein kinase
Arachidonic Acid
skin (animal)
in vitro studies
carcinogenesis

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science
  • Agronomy and Crop Science
  • Nutrition and Dietetics

Cite this

@article{9ecf48ff86114e25ab8903c62d97415f,
title = "Bioavailability and stability issues in understanding the cancer preventive effects of tea polyphenols",
abstract = "The cancer preventive activities of tea (Camellia sinensis) have received a great deal of attention from researchers and the general public. The inhibition of carcinogenesis by tea and tea polyphenols has been demonstrated in different animal models of skin, lung, intestinal and other cancer types by many investigators. Numerous mechanisms for the cancer preventive activity have been proposed based on studies of human cancer cell lines without considering the bioavailability of tea polyphenols. The proposed inhibition of mitogen activated protein (MAP) kinases, aberrant arachidonic acid metabolism, nuclear factor κB (NFκB) and activator protein 1 (AP-1) mediated transcription, growth factor-mediated signaling, and other activities could lead to the inhibition of tumor cell growth or induction of apoptosis as well as the inhibition of angiogenesis. In many cases, however, the concentrations of tea polyphenols required to observe these biological effects in vitro exceed the concentrations achievable in blood and tissues by 10- to 100-fold. In addition, in vitro studies are complicated by the fact that tea polyphenols are not stable and reactive oxygen species are generated under most cell culture conditions. It is not clear whether these reactions occur in vivo. From the bioavailability and stability viewpoints, we herein discuss the relevance of in vitro observations to the mechanisms of the cancer preventive activities of tea polyphenols in vivo.",
author = "Shengmin Sang and Lambert, {Joshua D.} and Yang, {Chung S.}",
year = "2006",
month = "11",
day = "1",
doi = "10.1002/jsfa.2660",
language = "English (US)",
volume = "86",
pages = "2256--2265",
journal = "Journal of the Science of Food and Agriculture",
issn = "0022-5142",
publisher = "John Wiley and Sons Ltd",
number = "14",

}

Bioavailability and stability issues in understanding the cancer preventive effects of tea polyphenols. / Sang, Shengmin; Lambert, Joshua D.; Yang, Chung S.

In: Journal of the science of food and agriculture, Vol. 86, No. 14, 01.11.2006, p. 2256-2265.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Bioavailability and stability issues in understanding the cancer preventive effects of tea polyphenols

AU - Sang, Shengmin

AU - Lambert, Joshua D.

AU - Yang, Chung S.

PY - 2006/11/1

Y1 - 2006/11/1

N2 - The cancer preventive activities of tea (Camellia sinensis) have received a great deal of attention from researchers and the general public. The inhibition of carcinogenesis by tea and tea polyphenols has been demonstrated in different animal models of skin, lung, intestinal and other cancer types by many investigators. Numerous mechanisms for the cancer preventive activity have been proposed based on studies of human cancer cell lines without considering the bioavailability of tea polyphenols. The proposed inhibition of mitogen activated protein (MAP) kinases, aberrant arachidonic acid metabolism, nuclear factor κB (NFκB) and activator protein 1 (AP-1) mediated transcription, growth factor-mediated signaling, and other activities could lead to the inhibition of tumor cell growth or induction of apoptosis as well as the inhibition of angiogenesis. In many cases, however, the concentrations of tea polyphenols required to observe these biological effects in vitro exceed the concentrations achievable in blood and tissues by 10- to 100-fold. In addition, in vitro studies are complicated by the fact that tea polyphenols are not stable and reactive oxygen species are generated under most cell culture conditions. It is not clear whether these reactions occur in vivo. From the bioavailability and stability viewpoints, we herein discuss the relevance of in vitro observations to the mechanisms of the cancer preventive activities of tea polyphenols in vivo.

AB - The cancer preventive activities of tea (Camellia sinensis) have received a great deal of attention from researchers and the general public. The inhibition of carcinogenesis by tea and tea polyphenols has been demonstrated in different animal models of skin, lung, intestinal and other cancer types by many investigators. Numerous mechanisms for the cancer preventive activity have been proposed based on studies of human cancer cell lines without considering the bioavailability of tea polyphenols. The proposed inhibition of mitogen activated protein (MAP) kinases, aberrant arachidonic acid metabolism, nuclear factor κB (NFκB) and activator protein 1 (AP-1) mediated transcription, growth factor-mediated signaling, and other activities could lead to the inhibition of tumor cell growth or induction of apoptosis as well as the inhibition of angiogenesis. In many cases, however, the concentrations of tea polyphenols required to observe these biological effects in vitro exceed the concentrations achievable in blood and tissues by 10- to 100-fold. In addition, in vitro studies are complicated by the fact that tea polyphenols are not stable and reactive oxygen species are generated under most cell culture conditions. It is not clear whether these reactions occur in vivo. From the bioavailability and stability viewpoints, we herein discuss the relevance of in vitro observations to the mechanisms of the cancer preventive activities of tea polyphenols in vivo.

UR - http://www.scopus.com/inward/record.url?scp=33750631721&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750631721&partnerID=8YFLogxK

U2 - 10.1002/jsfa.2660

DO - 10.1002/jsfa.2660

M3 - Review article

AN - SCOPUS:33750631721

VL - 86

SP - 2256

EP - 2265

JO - Journal of the Science of Food and Agriculture

JF - Journal of the Science of Food and Agriculture

SN - 0022-5142

IS - 14

ER -