Bioavailability, efficacy, and tolerance of two sustained-release theophylline dosage forms in adult patients with bronchial asthma

J. J. Trautlein, L. Demers, V. Esler, E. Field

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Twenty otherwise healthy adults with a diagnosis of reversible obstructive airways disease were treated for one month in a single-blind crossover study with approximately equivalent doses of Elixophyllin(®) SR capsules or Theo-Dur(®) tablets. Both products provided evidence of efficacy by improvement in pulmonary function tests, and both were well tolerated. There were no significant differences between the two products with regard to bioavailability, efficacy, or tolerance. Both dosage forms appeared to have similar kinetic properties within the context of the study.

Original languageEnglish (US)
Pages (from-to)252-262
Number of pages11
JournalClinical therapeutics
Volume4
Issue number4
StatePublished - Dec 1 1981

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

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