Bioavailable testosterone as a correlate of cognition, psychological status, quality of life, and sexual function in aging males: Implications for testosterone replacement therapy

P. J. Perry, B. C. Lund, S. Arndt, T. Holman, K. A. Bever-Stille, J. Paulsen, L. M. Demers

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Andropause is a syndrome described in aging males, is composed of a constellation of physical, sexual, and emotional symptoms, and is thought to be related to declining concentrations of serum testosterone. Numerous studies of testosterone replacement therapy in elderly hypogonadal males have documented the physical benefits of such treatment, but have failed to assess cognition, psychological functioning, and quality of life. Male outpatients greater or equal to 55 years of age completed cognitive, psychological, sexual, and quality of life assessments. A serum sample was provided for bioavailable testosterone assay. The associations between bioavailable testosterone concentrations and neuropsychological testing were assessed using Spearman rank correlation. Overall, bioavailable testosterone was not an important determinant of cognitive, psychological, or sexual functioning or of quality of life. The implications for future studies involving testosterone replacement therapy are discussed.

Original languageEnglish (US)
Pages (from-to)75-80
Number of pages6
JournalAnnals of Clinical Psychiatry
Volume13
Issue number2
DOIs
StatePublished - Sep 11 2001

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Bioavailable testosterone as a correlate of cognition, psychological status, quality of life, and sexual function in aging males: Implications for testosterone replacement therapy'. Together they form a unique fingerprint.

Cite this