Biochemical and pharmacological characterization of Trimersurus malabaricus snake venom

Raghavendra Gowda, Rajesh Rajaiah, Nataraj Angaswamy, Sharath Krishna, Vishwanath Bannikuppe Sannanayak

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Trimeresurus malabaricus is a venomous pit viper species endemic to southwestern part of India. In earlier reports, we have shown that envenomation by T. malabaricus venom leading to strong local tissue damage but the mechanism of action is not clearly revealed. Local tissue damage affected by T. malabaricus venom is of great importance since the poison has serious systemic effects including death in the case of multiple attacks. The present study details the major manifestations of T. malabaricus venom and the induction of local tissue damage, which suggests that most toxins are present in the form of hydrolytic enzymes. Hydrolytic activity of the enzymes was measured and the data indicated that protease and phospholipase A 2 activity was high which is responsible for local tissue damage. Furthermore, the role of hydrolytic enzymes in the induction of pathological events such as hemorrhage, edema, myotoxicity, and blood coagulation examination were assessed through animal models.

Original languageEnglish (US)
Pages (from-to)5904-5912
Number of pages9
JournalJournal of cellular biochemistry
Volume119
Issue number7
DOIs
StatePublished - Jul 2018

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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