Biodegradable poly[bis(ethyl alanato)phosphazene] - Poly(lactide-co- glycolide) blends: Miscibility and osteocompatibility evaluations

Lakshmi S. Nair, Jared D. Bender, Anurima Singh, Swaminathan Sethuraman, Yaser E. Greish, Paul W. Brown, Harry R. Allcock, Cato T. Laurencin

Research output: Contribution to journalConference article

8 Citations (Scopus)

Abstract

We have previously demonstrated that blending biodegradable glycine co-substituted polyphosphazenes with poly(lactide-co-glycolide) (PLAGA) results in novel biomaterials with versatile properties. The study showed that the degradation rate of polyphosphazene/PLAGA blends can be effectively controlled by varying the blend composition while at the same time the degradation products of polyphosphazenes effectively neutralized the acidic degradation products of PLAGA. In the present study, novel blends of hydrophobic, biodegradable polyphosphazene, poly[bis(ethyl alanato) phosphazene] (PNEA) and PLAGA (LA: GA; 85:15) were developed as candidates for bone tissue engineering applications. Two different blend compositions were developed by blending PNEA and PLAGA having weight ratios of 25:75 (Blend-1) and 50:50 (Blend-2) by the mutual solvent technique using dichloromethane as the solvent. The irascibility of the blends was determined using differential scanning calorimetry (DSC), fourier transform-infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM). Surface analysis of the blends by SEM revealed a smooth uniform surface for Blend-1, whereas Blend-2 showed evidence of phase separation. PNEA is not completely miscible with PLAGA, as evidenced from DSC and FT-IR measurements. The osteocompatibilities of Blend-1 and Blend-2 were compared to those of parent polymers by following the adhesion and proliferation of primary rat osteoblast cells on two dimensional (2-D) polymer and blend films over a 21 day period in culture. Blend films showed significantly higher cell numbers on the surface compared to PLAGA and PNEA films.

Original languageEnglish (US)
Article numberY9.7
Pages (from-to)319-325
Number of pages7
JournalMaterials Research Society Symposium Proceedings
Volume844
StatePublished - Jun 20 2005
EventMechanical Properties of Bioinspired and Biological Materials - Boston, MA, United States
Duration: Nov 29 2004Dec 2 2004

Fingerprint

phosphazene
Polyglactin 910
solubility
Solubility
Degradation
Fourier transform infrared spectroscopy
evaluation
Differential scanning calorimetry
Polymers
Scanning electron microscopy
Methylene Chloride
Osteoblasts
Surface analysis
Dichloromethane
Biocompatible Materials
Chemical analysis
Tissue engineering
Biomaterials
Phase separation
Glycine

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Nair, L. S., Bender, J. D., Singh, A., Sethuraman, S., Greish, Y. E., Brown, P. W., ... Laurencin, C. T. (2005). Biodegradable poly[bis(ethyl alanato)phosphazene] - Poly(lactide-co- glycolide) blends: Miscibility and osteocompatibility evaluations. Materials Research Society Symposium Proceedings, 844, 319-325. [Y9.7].
Nair, Lakshmi S. ; Bender, Jared D. ; Singh, Anurima ; Sethuraman, Swaminathan ; Greish, Yaser E. ; Brown, Paul W. ; Allcock, Harry R. ; Laurencin, Cato T. / Biodegradable poly[bis(ethyl alanato)phosphazene] - Poly(lactide-co- glycolide) blends : Miscibility and osteocompatibility evaluations. In: Materials Research Society Symposium Proceedings. 2005 ; Vol. 844. pp. 319-325.
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abstract = "We have previously demonstrated that blending biodegradable glycine co-substituted polyphosphazenes with poly(lactide-co-glycolide) (PLAGA) results in novel biomaterials with versatile properties. The study showed that the degradation rate of polyphosphazene/PLAGA blends can be effectively controlled by varying the blend composition while at the same time the degradation products of polyphosphazenes effectively neutralized the acidic degradation products of PLAGA. In the present study, novel blends of hydrophobic, biodegradable polyphosphazene, poly[bis(ethyl alanato) phosphazene] (PNEA) and PLAGA (LA: GA; 85:15) were developed as candidates for bone tissue engineering applications. Two different blend compositions were developed by blending PNEA and PLAGA having weight ratios of 25:75 (Blend-1) and 50:50 (Blend-2) by the mutual solvent technique using dichloromethane as the solvent. The irascibility of the blends was determined using differential scanning calorimetry (DSC), fourier transform-infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM). Surface analysis of the blends by SEM revealed a smooth uniform surface for Blend-1, whereas Blend-2 showed evidence of phase separation. PNEA is not completely miscible with PLAGA, as evidenced from DSC and FT-IR measurements. The osteocompatibilities of Blend-1 and Blend-2 were compared to those of parent polymers by following the adhesion and proliferation of primary rat osteoblast cells on two dimensional (2-D) polymer and blend films over a 21 day period in culture. Blend films showed significantly higher cell numbers on the surface compared to PLAGA and PNEA films.",
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Biodegradable poly[bis(ethyl alanato)phosphazene] - Poly(lactide-co- glycolide) blends : Miscibility and osteocompatibility evaluations. / Nair, Lakshmi S.; Bender, Jared D.; Singh, Anurima; Sethuraman, Swaminathan; Greish, Yaser E.; Brown, Paul W.; Allcock, Harry R.; Laurencin, Cato T.

In: Materials Research Society Symposium Proceedings, Vol. 844, Y9.7, 20.06.2005, p. 319-325.

Research output: Contribution to journalConference article

TY - JOUR

T1 - Biodegradable poly[bis(ethyl alanato)phosphazene] - Poly(lactide-co- glycolide) blends

T2 - Miscibility and osteocompatibility evaluations

AU - Nair, Lakshmi S.

AU - Bender, Jared D.

AU - Singh, Anurima

AU - Sethuraman, Swaminathan

AU - Greish, Yaser E.

AU - Brown, Paul W.

AU - Allcock, Harry R.

AU - Laurencin, Cato T.

PY - 2005/6/20

Y1 - 2005/6/20

N2 - We have previously demonstrated that blending biodegradable glycine co-substituted polyphosphazenes with poly(lactide-co-glycolide) (PLAGA) results in novel biomaterials with versatile properties. The study showed that the degradation rate of polyphosphazene/PLAGA blends can be effectively controlled by varying the blend composition while at the same time the degradation products of polyphosphazenes effectively neutralized the acidic degradation products of PLAGA. In the present study, novel blends of hydrophobic, biodegradable polyphosphazene, poly[bis(ethyl alanato) phosphazene] (PNEA) and PLAGA (LA: GA; 85:15) were developed as candidates for bone tissue engineering applications. Two different blend compositions were developed by blending PNEA and PLAGA having weight ratios of 25:75 (Blend-1) and 50:50 (Blend-2) by the mutual solvent technique using dichloromethane as the solvent. The irascibility of the blends was determined using differential scanning calorimetry (DSC), fourier transform-infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM). Surface analysis of the blends by SEM revealed a smooth uniform surface for Blend-1, whereas Blend-2 showed evidence of phase separation. PNEA is not completely miscible with PLAGA, as evidenced from DSC and FT-IR measurements. The osteocompatibilities of Blend-1 and Blend-2 were compared to those of parent polymers by following the adhesion and proliferation of primary rat osteoblast cells on two dimensional (2-D) polymer and blend films over a 21 day period in culture. Blend films showed significantly higher cell numbers on the surface compared to PLAGA and PNEA films.

AB - We have previously demonstrated that blending biodegradable glycine co-substituted polyphosphazenes with poly(lactide-co-glycolide) (PLAGA) results in novel biomaterials with versatile properties. The study showed that the degradation rate of polyphosphazene/PLAGA blends can be effectively controlled by varying the blend composition while at the same time the degradation products of polyphosphazenes effectively neutralized the acidic degradation products of PLAGA. In the present study, novel blends of hydrophobic, biodegradable polyphosphazene, poly[bis(ethyl alanato) phosphazene] (PNEA) and PLAGA (LA: GA; 85:15) were developed as candidates for bone tissue engineering applications. Two different blend compositions were developed by blending PNEA and PLAGA having weight ratios of 25:75 (Blend-1) and 50:50 (Blend-2) by the mutual solvent technique using dichloromethane as the solvent. The irascibility of the blends was determined using differential scanning calorimetry (DSC), fourier transform-infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM). Surface analysis of the blends by SEM revealed a smooth uniform surface for Blend-1, whereas Blend-2 showed evidence of phase separation. PNEA is not completely miscible with PLAGA, as evidenced from DSC and FT-IR measurements. The osteocompatibilities of Blend-1 and Blend-2 were compared to those of parent polymers by following the adhesion and proliferation of primary rat osteoblast cells on two dimensional (2-D) polymer and blend films over a 21 day period in culture. Blend films showed significantly higher cell numbers on the surface compared to PLAGA and PNEA films.

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M3 - Conference article

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JO - Materials Research Society Symposium - Proceedings

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