Bioerodible polymers with a phosphorus-nitrogen backbone

H. R. Allcock, S. Kwon, S. R. Pucher

Research output: Contribution to journalConference article

5 Scopus citations

Abstract

Four different classes of polyphosphazenes that can be designated as 'bioerodible' have been synthesized. In each polymer system, at least one of the side groups is hydrolytically labile. The degradation products of these reactions are phosphates, ammonia, glucose, and methylamine. The potential applications of α-D-glucosyl polyphosphazenes are of considerable interest. Drug molecules or peptides could be directly linked to the water-soluble polymer or to a crosslinked hydrogel. In vivo hydrolysis would release the glucose-bound pharmaceutical. Also, by use of a water-insolublizing cosubstituent, the potential exists to design a monlithic drug delivery system.

Original languageEnglish (US)
Pages (from-to)180-181
Number of pages2
JournalAmerican Chemical Society, Polymer Preprints, Division of Polymer Chemistry
Volume31
Issue number2
StatePublished - Aug 1 1990
EventPapers presented at the Washington, DC Meeting 1990 of the ACS, Division of Polymer Chemistry - Washington, DC, USA
Duration: Aug 26 1990Aug 31 1990

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Polymers and Plastics
  • Engineering(all)

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