Bioerodible polymers with a phosphorus-nitrogen backbone

H. R. Allcock, S. Kwon, S. R. Pucher

Research output: Contribution to journalConference article

5 Citations (Scopus)

Abstract

Four different classes of polyphosphazenes that can be designated as 'bioerodible' have been synthesized. In each polymer system, at least one of the side groups is hydrolytically labile. The degradation products of these reactions are phosphates, ammonia, glucose, and methylamine. The potential applications of α-D-glucosyl polyphosphazenes are of considerable interest. Drug molecules or peptides could be directly linked to the water-soluble polymer or to a crosslinked hydrogel. In vivo hydrolysis would release the glucose-bound pharmaceutical. Also, by use of a water-insolublizing cosubstituent, the potential exists to design a monlithic drug delivery system.

Original languageEnglish (US)
Pages (from-to)180-181
Number of pages2
JournalAmerican Chemical Society, Polymer Preprints, Division of Polymer Chemistry
Volume31
Issue number2
StatePublished - Aug 1 1990
EventPapers presented at the Washington, DC Meeting 1990 of the ACS, Division of Polymer Chemistry - Washington, DC, USA
Duration: Aug 26 1990Aug 31 1990

Fingerprint

Phosphorus
Glucose
Polymers
Nitrogen
Water
Hydrogel
Ammonia
Hydrogels
Pharmaceutical Preparations
Drug products
Peptides
Hydrolysis
Phosphates
Degradation
Molecules
Drug Delivery Systems
methylamine

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Polymers and Plastics
  • Engineering(all)

Cite this

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abstract = "Four different classes of polyphosphazenes that can be designated as 'bioerodible' have been synthesized. In each polymer system, at least one of the side groups is hydrolytically labile. The degradation products of these reactions are phosphates, ammonia, glucose, and methylamine. The potential applications of α-D-glucosyl polyphosphazenes are of considerable interest. Drug molecules or peptides could be directly linked to the water-soluble polymer or to a crosslinked hydrogel. In vivo hydrolysis would release the glucose-bound pharmaceutical. Also, by use of a water-insolublizing cosubstituent, the potential exists to design a monlithic drug delivery system.",
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Bioerodible polymers with a phosphorus-nitrogen backbone. / Allcock, H. R.; Kwon, S.; Pucher, S. R.

In: American Chemical Society, Polymer Preprints, Division of Polymer Chemistry, Vol. 31, No. 2, 01.08.1990, p. 180-181.

Research output: Contribution to journalConference article

TY - JOUR

T1 - Bioerodible polymers with a phosphorus-nitrogen backbone

AU - Allcock, H. R.

AU - Kwon, S.

AU - Pucher, S. R.

PY - 1990/8/1

Y1 - 1990/8/1

N2 - Four different classes of polyphosphazenes that can be designated as 'bioerodible' have been synthesized. In each polymer system, at least one of the side groups is hydrolytically labile. The degradation products of these reactions are phosphates, ammonia, glucose, and methylamine. The potential applications of α-D-glucosyl polyphosphazenes are of considerable interest. Drug molecules or peptides could be directly linked to the water-soluble polymer or to a crosslinked hydrogel. In vivo hydrolysis would release the glucose-bound pharmaceutical. Also, by use of a water-insolublizing cosubstituent, the potential exists to design a monlithic drug delivery system.

AB - Four different classes of polyphosphazenes that can be designated as 'bioerodible' have been synthesized. In each polymer system, at least one of the side groups is hydrolytically labile. The degradation products of these reactions are phosphates, ammonia, glucose, and methylamine. The potential applications of α-D-glucosyl polyphosphazenes are of considerable interest. Drug molecules or peptides could be directly linked to the water-soluble polymer or to a crosslinked hydrogel. In vivo hydrolysis would release the glucose-bound pharmaceutical. Also, by use of a water-insolublizing cosubstituent, the potential exists to design a monlithic drug delivery system.

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JO - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry

JF - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry

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