Biogenesis of catecholestrogens: A mechanism for metabolic activation of estrogens.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Catecholestrogens (CE) are products of aromatic hydroxylation at C-2 or C-4 of primary estrogens and their synthetic steroidal agonists. CE are generated in a number of target organs where they may act as.local mediators of estrogen action. They have also been implicated in carcinogenesis, since CE are substrates for redox cycling and hence, a potential source of free radicals. Biogenesis of CE can occur via two mechanisms, one monooxygenase and the other peroxidative. These two mechanisms have different implications for estrogen action because of differences in their co-factor requirement and in the amounts of 2- and 4-hydroxylated estrogens they generate. This review focuses on the phase I enzymes, the cytochromes P450 that catalyze 2- and 4-hydroxylation of estrogens, on the distinctive properties of 2- and 4-OHCE and on the phase II enzymes responsible for their inactivation.

Original languageEnglish (US)
Pages (from-to)241-251
Number of pages11
JournalPolycyclic Aromatic Compounds
Volume6
Issue number1-4
DOIs
StatePublished - Jan 1994

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Catechol Estrogens
Estrogens
Chemical activation
Hydroxylation
Estradiol Congeners
Enzymes
Mixed Function Oxygenases
Cytochrome P-450 Enzyme System
Free Radicals
Free radicals
Substrates

All Science Journal Classification (ASJC) codes

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

Cite this

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title = "Biogenesis of catecholestrogens: A mechanism for metabolic activation of estrogens.",
abstract = "Catecholestrogens (CE) are products of aromatic hydroxylation at C-2 or C-4 of primary estrogens and their synthetic steroidal agonists. CE are generated in a number of target organs where they may act as.local mediators of estrogen action. They have also been implicated in carcinogenesis, since CE are substrates for redox cycling and hence, a potential source of free radicals. Biogenesis of CE can occur via two mechanisms, one monooxygenase and the other peroxidative. These two mechanisms have different implications for estrogen action because of differences in their co-factor requirement and in the amounts of 2- and 4-hydroxylated estrogens they generate. This review focuses on the phase I enzymes, the cytochromes P450 that catalyze 2- and 4-hydroxylation of estrogens, on the distinctive properties of 2- and 4-OHCE and on the phase II enzymes responsible for their inactivation.",
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Biogenesis of catecholestrogens : A mechanism for metabolic activation of estrogens. / Weisz, Judith.

In: Polycyclic Aromatic Compounds, Vol. 6, No. 1-4, 01.1994, p. 241-251.

Research output: Contribution to journalArticle

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