Biologic characteristics of four Ewing's sarcomas

M. Linda Workman, Shirley W. Soukup, John Neely, Jeffrey Whitsett, Edgar Ballard, Beatrice Lampkin

Research output: Contribution to journalArticle

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Abstract

Four Ewing's sarcomas were examined for chromosomal characteristecs, growth in cell culture, tumorigenicity in nude mice, and presence of β-adrenergic receptors. Three tumors were from untreated patients (one obtained directly from the patient and two after growth in nude mice) and one was a metastatic lesion obtained after treatment. All four tumors were diploid or near-diploid, with one or more structural rearrangements. In the metastatic lesion. 21 abnormalities were seen. No specific chromosome aberration was found to be common to all four tumors, although a t(1,16) was observed in two and a t(11;22) in two. Abnormalities involving chromosomes #1, #3, #11, #13, #16, and #22 were each found in two of four tumors. All four tumors were tumorigenic in nude mice; two grew well in cell culture, one of which became an established line, and all four expressed high concentrations of β-adrenergic receptors.

Original languageEnglish (US)
Pages (from-to)215-225
Number of pages11
JournalCancer Genetics and Cytogenetics
Volume15
Issue number3-4
DOIs
StatePublished - Feb 15 1985

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Ewing's Sarcoma
Nude Mice
Neoplasms
Diploidy
Adrenergic Receptors
Cell Culture Techniques
Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 1
Growth
Chromosome Aberrations

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Workman, M. L., Soukup, S. W., Neely, J., Whitsett, J., Ballard, E., & Lampkin, B. (1985). Biologic characteristics of four Ewing's sarcomas. Cancer Genetics and Cytogenetics, 15(3-4), 215-225. https://doi.org/10.1016/0165-4608(85)90165-7
Workman, M. Linda ; Soukup, Shirley W. ; Neely, John ; Whitsett, Jeffrey ; Ballard, Edgar ; Lampkin, Beatrice. / Biologic characteristics of four Ewing's sarcomas. In: Cancer Genetics and Cytogenetics. 1985 ; Vol. 15, No. 3-4. pp. 215-225.
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Workman, ML, Soukup, SW, Neely, J, Whitsett, J, Ballard, E & Lampkin, B 1985, 'Biologic characteristics of four Ewing's sarcomas', Cancer Genetics and Cytogenetics, vol. 15, no. 3-4, pp. 215-225. https://doi.org/10.1016/0165-4608(85)90165-7

Biologic characteristics of four Ewing's sarcomas. / Workman, M. Linda; Soukup, Shirley W.; Neely, John; Whitsett, Jeffrey; Ballard, Edgar; Lampkin, Beatrice.

In: Cancer Genetics and Cytogenetics, Vol. 15, No. 3-4, 15.02.1985, p. 215-225.

Research output: Contribution to journalArticle

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Workman ML, Soukup SW, Neely J, Whitsett J, Ballard E, Lampkin B. Biologic characteristics of four Ewing's sarcomas. Cancer Genetics and Cytogenetics. 1985 Feb 15;15(3-4):215-225. https://doi.org/10.1016/0165-4608(85)90165-7