Biologic characteristics of four Ewing's sarcomas

M. Linda Workman, Shirley W. Soukup, John E. Neely, Jeffrey Whitsett, Edgar Ballard, Beatrice Lampkin

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Abstract

Four Ewing's sarcomas were examined for chromosomal characteristecs, growth in cell culture, tumorigenicity in nude mice, and presence of β-adrenergic receptors. Three tumors were from untreated patients (one obtained directly from the patient and two after growth in nude mice) and one was a metastatic lesion obtained after treatment. All four tumors were diploid or near-diploid, with one or more structural rearrangements. In the metastatic lesion. 21 abnormalities were seen. No specific chromosome aberration was found to be common to all four tumors, although a t(1,16) was observed in two and a t(11;22) in two. Abnormalities involving chromosomes #1, #3, #11, #13, #16, and #22 were each found in two of four tumors. All four tumors were tumorigenic in nude mice; two grew well in cell culture, one of which became an established line, and all four expressed high concentrations of β-adrenergic receptors.

Original languageEnglish (US)
Pages (from-to)215-225
Number of pages11
JournalCancer Genetics and Cytogenetics
Volume15
Issue number3-4
DOIs
StatePublished - Feb 15 1985

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All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Workman, M. L., Soukup, S. W., Neely, J. E., Whitsett, J., Ballard, E., & Lampkin, B. (1985). Biologic characteristics of four Ewing's sarcomas. Cancer Genetics and Cytogenetics, 15(3-4), 215-225. https://doi.org/10.1016/0165-4608(85)90165-7