Biological cluster mass spectrometry

Nicholas Winograd, Barbara J. Garrison

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

This article reviews the new physics and new applications of secondary ion mass spectrometry using cluster ion probes. These probes, particularly C 60, exhibit enhanced molecular desorption with improved sensitivity owing to the unique nature of the energy-deposition process. In addition, these projectiles are capable of eroding molecular solids while retaining the molecular specificity of mass spectrometry. When the beams are microfocused to a spot on the sample, bioimaging experiments in two and three dimensions are feasible. We describe emerging theoretical models that allow the energy-deposition process to be understood on an atomic and molecular basis. Moreover, experiments on model systems are described that allow protocols for imaging on biological materials to be implemented. Finally, we present recent applications of imaging to biological tissue and single cells to illustrate the future directions of this methodology.

Original languageEnglish (US)
Pages (from-to)305-322
Number of pages18
JournalAnnual Review of Physical Chemistry
Volume61
DOIs
StatePublished - May 5 2010

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry

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