Biological switches and clocks

John J. Tyson, Reka Albert, Albert Goldbeter, Peter Ruoff, Jill Sible

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

To introduce this special issue on biological switches and clocks, we review the historical development of mathematical models of bistability and oscillations in chemical reaction networks. In the 1960s and 1970s, these models were limited to well-studied biochemical examples, such as glycolytic oscillations and cyclic AMP signalling. After the molecular genetics revolution of the 1980s, the field of molecular cell biology was thrown wide open to mathematical modellers. We review recent advances in modelling the gene-protein interaction networks that control circadian rhythms, cell cycle progression, signal processing and the design of synthetic gene networks.

Original languageEnglish (US)
Pages (from-to)S1-S8
JournalJournal of the Royal Society Interface
Volume5
Issue numberSUPPL. 1
DOIs
StatePublished - Aug 6 2008

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering

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    Tyson, J. J., Albert, R., Goldbeter, A., Ruoff, P., & Sible, J. (2008). Biological switches and clocks. Journal of the Royal Society Interface, 5(SUPPL. 1), S1-S8. https://doi.org/10.1098/rsif.2008.0179.focus