Biologically active biotin derivatives of schweinfurthin F

Natalie C. Ulrich, Craig H. Kuder, Raymond Hohl, David F. Wiemer

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

As a prelude to efforts to identify schweinfurthin binding proteins, an ester conjugate and an amide conjugate of schweinfurthin F and biotin have been prepared by chemical synthesis. These compounds maintain activity in SF-295 cells comparable to the parent system, and display the lower potency in A549 cells that is a characteristic of the schweinfurthin pattern of activity.

Original languageEnglish (US)
Pages (from-to)6716-6720
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number22
DOIs
StatePublished - Nov 15 2010

Fingerprint

Biotin
Amides
Carrier Proteins
Esters
Derivatives
schweinfurthin F
A549 Cells

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Ulrich, Natalie C. ; Kuder, Craig H. ; Hohl, Raymond ; Wiemer, David F. / Biologically active biotin derivatives of schweinfurthin F. In: Bioorganic and Medicinal Chemistry Letters. 2010 ; Vol. 20, No. 22. pp. 6716-6720.
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Biologically active biotin derivatives of schweinfurthin F. / Ulrich, Natalie C.; Kuder, Craig H.; Hohl, Raymond; Wiemer, David F.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 20, No. 22, 15.11.2010, p. 6716-6720.

Research output: Contribution to journalArticle

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AU - Wiemer, David F.

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