Biology of the Blood-Brain and Blood-Brain Tumor Barriers

Herbert H. Engelhard, Gregory D. Arnone, Ankit I. Mehta, Martin K. Nicholas

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The blood-brain barrier (BBB) provides the central nervous system (CNS) with a privileged environment by blocking entry of toxic substances, maintaining optimal concentrations of physiologic molecules, and actively eliminating unwanted substances such as metabolic by-products. The normal BBB is composed of a continuous layer of endothelial cells, constituting the luminal surface of more than 99% of the capillaries of the brain and spinal cord. These cells lack fenestrations and have high resistance tight junctions, which (along with adjacent components of the Neurovascular Unit (NVU)) greatly limit the free passage of molecules. The capillary endothelium within brain tumors has been called the "blood-brain tumor barrier." This chapter provides a general introduction to BBB-related cellular and molecular biology, physiology, and some relevant therapeutic issues. Topics discussed in this chapter include recent information related to immunology and the BBB, cerebral microdialysis, glioma stem cells, and the "BBB on a chip." While new strategies are continually being developed, the clinician's ability to administer safe and effective drugs that cross the BBB continues to be a critical issue for patients with malignant gliomas and brain micrometastases.

Original languageEnglish (US)
Title of host publicationHandbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages113-125
Number of pages13
ISBN (Print)9780128121009
DOIs
StatePublished - Apr 24 2018

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Neuroscience(all)

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    Engelhard, H. H., Arnone, G. D., Mehta, A. I., & Nicholas, M. K. (2018). Biology of the Blood-Brain and Blood-Brain Tumor Barriers. In Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy: Second Edition (pp. 113-125). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-812100-9.00008-5