Abstract

Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of transcription factors. PPARs respond to specific ligands by alternating gene expression in a cell-, developmental-, and sex-specific manner. Three subtypes of this receptor have been discovered (PPARα, β and γ), each apparently evolving to fulfill different biological niches. Although PPARs were initially characterized as being activated by xenobiotic peroxisome proliferators (PPs), subsequently it was shown these proteins respond to endogenous fatty acids, leukotrienes and prostaglandins. In addition, PPARs control a variety of target genes involved in lipid homeostasis, diabetes and cancer. In this review article the importance of the PPAR subtypes in lipid homeostasis is discussed in the context of physiologic effectors as well as phenotypes of transgenic mice in which PPAR expression is ablated.

Original languageEnglish (US)
Pages (from-to)233-257
Number of pages25
JournalComments on Toxicology
Volume7
Issue number3
StatePublished - 2001

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Peroxisome Proliferator-Activated Receptors
Homeostasis
Peroxisome Proliferators
Lipids
Leukotrienes
Xenobiotics
Cytoplasmic and Nuclear Receptors
Medical problems
Gene expression
Transgenic Mice
Prostaglandins
Transcription Factors
Fatty Acids
Genes
Ligands
Phenotype
Gene Expression

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

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title = "Biology of the PPAR family of receptors",
abstract = "Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of transcription factors. PPARs respond to specific ligands by alternating gene expression in a cell-, developmental-, and sex-specific manner. Three subtypes of this receptor have been discovered (PPARα, β and γ), each apparently evolving to fulfill different biological niches. Although PPARs were initially characterized as being activated by xenobiotic peroxisome proliferators (PPs), subsequently it was shown these proteins respond to endogenous fatty acids, leukotrienes and prostaglandins. In addition, PPARs control a variety of target genes involved in lipid homeostasis, diabetes and cancer. In this review article the importance of the PPAR subtypes in lipid homeostasis is discussed in the context of physiologic effectors as well as phenotypes of transgenic mice in which PPAR expression is ablated.",
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pages = "233--257",
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Biology of the PPAR family of receptors. / Vanden Heuvel, John Patrick; Peters, Jeffrey Maurice.

In: Comments on Toxicology, Vol. 7, No. 3, 2001, p. 233-257.

Research output: Contribution to journalReview article

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AU - Vanden Heuvel, John Patrick

AU - Peters, Jeffrey Maurice

PY - 2001

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N2 - Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of transcription factors. PPARs respond to specific ligands by alternating gene expression in a cell-, developmental-, and sex-specific manner. Three subtypes of this receptor have been discovered (PPARα, β and γ), each apparently evolving to fulfill different biological niches. Although PPARs were initially characterized as being activated by xenobiotic peroxisome proliferators (PPs), subsequently it was shown these proteins respond to endogenous fatty acids, leukotrienes and prostaglandins. In addition, PPARs control a variety of target genes involved in lipid homeostasis, diabetes and cancer. In this review article the importance of the PPAR subtypes in lipid homeostasis is discussed in the context of physiologic effectors as well as phenotypes of transgenic mice in which PPAR expression is ablated.

AB - Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of transcription factors. PPARs respond to specific ligands by alternating gene expression in a cell-, developmental-, and sex-specific manner. Three subtypes of this receptor have been discovered (PPARα, β and γ), each apparently evolving to fulfill different biological niches. Although PPARs were initially characterized as being activated by xenobiotic peroxisome proliferators (PPs), subsequently it was shown these proteins respond to endogenous fatty acids, leukotrienes and prostaglandins. In addition, PPARs control a variety of target genes involved in lipid homeostasis, diabetes and cancer. In this review article the importance of the PPAR subtypes in lipid homeostasis is discussed in the context of physiologic effectors as well as phenotypes of transgenic mice in which PPAR expression is ablated.

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