Biology of trans-translation

Research output: Contribution to journalReview articlepeer-review

170 Scopus citations

Abstract

The trans-translation mechanism is a key component of multiple quality control pathways in bacteria that ensure proteins are synthesized with high fidelity in spite of challenges such as transcription errors, mRNA damage, and translational frameshifting. trans-Translation is performed by a ribonucleoprotein complex composed of tmRNA, a specialized RNA with properties of both a tRNA and an mRNA, and the small protein SmpB. tmRNA-SmpB interacts with translational complexes stalled at the 3′ end of an mRNA to release the stalled ribosomes and target the nascent polypeptides and mRNAs for degradation. In addition to quality control pathways, some genetic regulatory circuits use trans-translation to control gene expression. Diverse bacteria require trans-translation when they execute large changes in their genetic programs, including responding to stress, pathogenesis, and differentiation.

Original languageEnglish (US)
Pages (from-to)133-151
Number of pages19
JournalAnnual Review of Microbiology
Volume62
DOIs
StatePublished - 2008

All Science Journal Classification (ASJC) codes

  • Microbiology

Fingerprint

Dive into the research topics of 'Biology of trans-translation'. Together they form a unique fingerprint.

Cite this