Biomarker enables molecular specific optical detection of transplant rejection

Qiang Tu, Yoon Gi Chung, Dianjun Cao, Shuko Harada, Christine S. Cheng, Howard Eisen, Chang Chang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Using serotonin as the biomarker, spatially re-solved Raman spectroscopy successfully detects heart transplant rejection without exogenous labeling and chemical fixation. The strong and characteristic Raman spectral signature of serotonin enables this direct optical detection without re-sorting to complicated data processing procedures. As the role of serotonin in various immune responses becomes increasingly recognized, this work presents a new paradigm in utilizing Raman spectroscopy as a clinically viable molecular specific diagnostic tool.

Original languageEnglish (US)
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering
Subtitle of host publicationDiagnostic and Therapeutic Instrumentation, Clinical Engineering
Pages740-743
Number of pages4
Edition7
DOIs
StatePublished - Dec 1 2009
EventWorld Congress on Medical Physics and Biomedical Engineering: Diagnostic and Therapeutic Instrumentation, Clinical Engineering - Munich, Germany
Duration: Sep 7 2009Sep 12 2009

Publication series

NameIFMBE Proceedings
Number7
Volume25
ISSN (Print)1680-0737

Other

OtherWorld Congress on Medical Physics and Biomedical Engineering: Diagnostic and Therapeutic Instrumentation, Clinical Engineering
CountryGermany
CityMunich
Period9/7/099/12/09

Fingerprint

Transplants
Biomarkers
Raman spectroscopy
Serotonin
Sorting
Labeling

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomedical Engineering

Cite this

Tu, Q., Chung, Y. G., Cao, D., Harada, S., Cheng, C. S., Eisen, H., & Chang, C. (2009). Biomarker enables molecular specific optical detection of transplant rejection. In World Congress on Medical Physics and Biomedical Engineering: Diagnostic and Therapeutic Instrumentation, Clinical Engineering (7 ed., pp. 740-743). (IFMBE Proceedings; Vol. 25, No. 7). https://doi.org/10.1007/978-3-642-03885-3-205
Tu, Qiang ; Chung, Yoon Gi ; Cao, Dianjun ; Harada, Shuko ; Cheng, Christine S. ; Eisen, Howard ; Chang, Chang. / Biomarker enables molecular specific optical detection of transplant rejection. World Congress on Medical Physics and Biomedical Engineering: Diagnostic and Therapeutic Instrumentation, Clinical Engineering. 7. ed. 2009. pp. 740-743 (IFMBE Proceedings; 7).
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abstract = "Using serotonin as the biomarker, spatially re-solved Raman spectroscopy successfully detects heart transplant rejection without exogenous labeling and chemical fixation. The strong and characteristic Raman spectral signature of serotonin enables this direct optical detection without re-sorting to complicated data processing procedures. As the role of serotonin in various immune responses becomes increasingly recognized, this work presents a new paradigm in utilizing Raman spectroscopy as a clinically viable molecular specific diagnostic tool.",
author = "Qiang Tu and Chung, {Yoon Gi} and Dianjun Cao and Shuko Harada and Cheng, {Christine S.} and Howard Eisen and Chang Chang",
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Tu, Q, Chung, YG, Cao, D, Harada, S, Cheng, CS, Eisen, H & Chang, C 2009, Biomarker enables molecular specific optical detection of transplant rejection. in World Congress on Medical Physics and Biomedical Engineering: Diagnostic and Therapeutic Instrumentation, Clinical Engineering. 7 edn, IFMBE Proceedings, no. 7, vol. 25, pp. 740-743, World Congress on Medical Physics and Biomedical Engineering: Diagnostic and Therapeutic Instrumentation, Clinical Engineering, Munich, Germany, 9/7/09. https://doi.org/10.1007/978-3-642-03885-3-205

Biomarker enables molecular specific optical detection of transplant rejection. / Tu, Qiang; Chung, Yoon Gi; Cao, Dianjun; Harada, Shuko; Cheng, Christine S.; Eisen, Howard; Chang, Chang.

World Congress on Medical Physics and Biomedical Engineering: Diagnostic and Therapeutic Instrumentation, Clinical Engineering. 7. ed. 2009. p. 740-743 (IFMBE Proceedings; Vol. 25, No. 7).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Tu Q, Chung YG, Cao D, Harada S, Cheng CS, Eisen H et al. Biomarker enables molecular specific optical detection of transplant rejection. In World Congress on Medical Physics and Biomedical Engineering: Diagnostic and Therapeutic Instrumentation, Clinical Engineering. 7 ed. 2009. p. 740-743. (IFMBE Proceedings; 7). https://doi.org/10.1007/978-3-642-03885-3-205