Biomarker for ischemic stroke using metabolome

A clinician perspective

Evgeny Sidorov, Dharambir K. Sanghera, Jairam K.P. Vanamala

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Finding ischemic stroke biomarker is highly desirable because it can improve diagnosis even before a patient arrives to the hospital. Metabolome is one of new technologies that help to find biomarkers. Most metabolome-related ischemic stroke studies were done in Asia and had exploratory designs. Although failed to find specific biomarkers, they discovered several important metabolite-stroke associations which belong to three pathophysiological mechanisms: Excitotoxicity with activation of glutamate, resulting in the increase of glutamate derivatives proline and pyroglutamate; Oxidative stress with production of free radicals and perturbed concentrations of uric acid, matrix metalloproteinase-9, branch-chained amino acids, sphingolipids, homocysteine, asymmetric dimethylarginine, nitric oxide and folate cycle metabolites; and Stroke mediated inflammation, affecting phospholipid metabolism with perturbed levels of lysophosphatidylethanolamine and lysophosphatidylcholine. The discovered metabolite-stroke associations need further evaluation in prospective, high-quality studies with patients matched for age, risk factors, and medications.

Original languageEnglish (US)
Pages (from-to)31-41
Number of pages11
JournalJournal of Stroke
Volume21
Issue number1
DOIs
StatePublished - Jan 1 2019

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Metabolome
Biomarkers
Stroke
Glutamic Acid
Pyrrolidonecarboxylic Acid
Lysophosphatidylcholines
Sphingolipids
Age Factors
Matrix Metalloproteinase 9
Homocysteine
Uric Acid
Folic Acid
Proline
Free Radicals
Phospholipids
Nitric Oxide
Oxidative Stress
Inflammation
Technology
Amino Acids

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Sidorov, Evgeny ; Sanghera, Dharambir K. ; Vanamala, Jairam K.P. / Biomarker for ischemic stroke using metabolome : A clinician perspective. In: Journal of Stroke. 2019 ; Vol. 21, No. 1. pp. 31-41.
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Biomarker for ischemic stroke using metabolome : A clinician perspective. / Sidorov, Evgeny; Sanghera, Dharambir K.; Vanamala, Jairam K.P.

In: Journal of Stroke, Vol. 21, No. 1, 01.01.2019, p. 31-41.

Research output: Contribution to journalArticle

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