Biomechanics: Cell research and applications for the next decade

Dennis Discher, Cheng Dong, Jeffrey J. Fredberg, Farshid Guilak, Donald Ingber, Paul Janmey, Roger D. Kamm, Geert W. Schmid-Schönbein, Sheldon Weinbaum

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

With the recent revolution in Molecular Biology and the deciphering of the Human Genome, understanding of the building blocks that comprise living systems has advanced rapidly. We have yet to understand, however, how the physical forces that animate life affect the synthesis, folding, assembly, and function of these molecular building blocks. We are equally uncertain as to how these building blocks interact dynamically to create coupled regulatory networks from which integrative biological behaviors emerge. Here we review recent advances in the field of biomechanics at the cellular and molecular levels, and set forth challenges confronting the field. Living systems work and move as multi-molecular collectives, and in order to understand key aspects of health and disease we must first be able to explain how physical forces and mechanical structures contribute to the active material properties of living cells and tissues, as well as how these forces impact information processing and cellular decision making. Such insights will no doubt inform basic biology and rational engineering of effective new approaches to clinical therapy.

Original languageEnglish (US)
Pages (from-to)847-859
Number of pages13
JournalAnnals of Biomedical Engineering
Volume37
Issue number5
DOIs
StatePublished - May 1 2009

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Molecular biology
Biomechanics
Materials properties
Genes
Decision making
Cells
Health
Tissue

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

Cite this

Discher, D., Dong, C., Fredberg, J. J., Guilak, F., Ingber, D., Janmey, P., ... Weinbaum, S. (2009). Biomechanics: Cell research and applications for the next decade. Annals of Biomedical Engineering, 37(5), 847-859. https://doi.org/10.1007/s10439-009-9661-x
Discher, Dennis ; Dong, Cheng ; Fredberg, Jeffrey J. ; Guilak, Farshid ; Ingber, Donald ; Janmey, Paul ; Kamm, Roger D. ; Schmid-Schönbein, Geert W. ; Weinbaum, Sheldon. / Biomechanics : Cell research and applications for the next decade. In: Annals of Biomedical Engineering. 2009 ; Vol. 37, No. 5. pp. 847-859.
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Discher, D, Dong, C, Fredberg, JJ, Guilak, F, Ingber, D, Janmey, P, Kamm, RD, Schmid-Schönbein, GW & Weinbaum, S 2009, 'Biomechanics: Cell research and applications for the next decade', Annals of Biomedical Engineering, vol. 37, no. 5, pp. 847-859. https://doi.org/10.1007/s10439-009-9661-x

Biomechanics : Cell research and applications for the next decade. / Discher, Dennis; Dong, Cheng; Fredberg, Jeffrey J.; Guilak, Farshid; Ingber, Donald; Janmey, Paul; Kamm, Roger D.; Schmid-Schönbein, Geert W.; Weinbaum, Sheldon.

In: Annals of Biomedical Engineering, Vol. 37, No. 5, 01.05.2009, p. 847-859.

Research output: Contribution to journalArticle

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