Biomechanics of blast TBI with time-resolved consecutive primary, secondary, and tertiary loads

Andrzej Przekwas, Harsha T. Garimella, X. Gary Tan, Z. J. Chen, Yuyang Miao, Vincent Harrand, Reuben H. Kraft, Raj K. Gupta

Research output: Contribution to journalArticle

Abstract

Blast-induced traumatic brain injury (bTBI) has become a signature casualty of recent military operations. In spite of significant clinical and preclinical TBI research, current understanding of injury mechanisms and short- A nd long-term outcomes is limited. Mathematical models of bTBI biomechanics may help in better understanding of injury mechanisms and in the development of improved neuroprotective strategies. Until present, bTBI has been analyzed as a single event of a blast pressure wave propagating through the brain. In many bTBI events, the loads on the body and the head are spatially and temporarily distributed, involving the primary intracranial pressure wave, followed by the head rotation and then by head impact on the ground. In such cases, the brain microstructures may experience time/space distributed (consecutive) damage and recovery events. The paper presents a novel multiscale simulation framework that couples the body/brain scale biomechanics with micro-scale mechanobiology to study the effects of micro-damage to neuro-axonal structures. Our results show that the micro-mechanical responses of neuro-axonal structures occur sequentially in time with "damage" and "relaxation" periods in different parts of the brain. A new integrated computational framework is described coupling the brain-scale biomechanics with micro-mechanical damage to axonal and synaptic structures.

Original languageEnglish (US)
Pages (from-to)195-205
Number of pages11
JournalMilitary medicine
Volume184
DOIs
StatePublished - Mar 1 2019

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Biomechanical Phenomena
Brain
Head
Biophysics
Wounds and Injuries
Intracranial Pressure
Theoretical Models
Pressure
Traumatic Brain Injury
Research

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

Przekwas, A., Garimella, H. T., Tan, X. G., Chen, Z. J., Miao, Y., Harrand, V., ... Gupta, R. K. (2019). Biomechanics of blast TBI with time-resolved consecutive primary, secondary, and tertiary loads. Military medicine, 184, 195-205. https://doi.org/10.1093/milmed/usy344
Przekwas, Andrzej ; Garimella, Harsha T. ; Tan, X. Gary ; Chen, Z. J. ; Miao, Yuyang ; Harrand, Vincent ; Kraft, Reuben H. ; Gupta, Raj K. / Biomechanics of blast TBI with time-resolved consecutive primary, secondary, and tertiary loads. In: Military medicine. 2019 ; Vol. 184. pp. 195-205.
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Przekwas, A, Garimella, HT, Tan, XG, Chen, ZJ, Miao, Y, Harrand, V, Kraft, RH & Gupta, RK 2019, 'Biomechanics of blast TBI with time-resolved consecutive primary, secondary, and tertiary loads', Military medicine, vol. 184, pp. 195-205. https://doi.org/10.1093/milmed/usy344

Biomechanics of blast TBI with time-resolved consecutive primary, secondary, and tertiary loads. / Przekwas, Andrzej; Garimella, Harsha T.; Tan, X. Gary; Chen, Z. J.; Miao, Yuyang; Harrand, Vincent; Kraft, Reuben H.; Gupta, Raj K.

In: Military medicine, Vol. 184, 01.03.2019, p. 195-205.

Research output: Contribution to journalArticle

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AU - Przekwas, Andrzej

AU - Garimella, Harsha T.

AU - Tan, X. Gary

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AU - Miao, Yuyang

AU - Harrand, Vincent

AU - Kraft, Reuben H.

AU - Gupta, Raj K.

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