Biomimetic, bioactive etheric polyphosphazenepoly(lactide-co-glycolide) blends for bone tissue engineering

Meng Deng, Lakshmi S. Nair, Syam P. Nukavarapu, Sangamesh G. Kumbar, Justin Lee Brown, Nicholas R. Krogman, Arlin L. Weikel, Harry R. Allcock, Cato T. Laurencin

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Abstract

The long-term goal of this work is to develop biomimetic polymer-based systems for bone regeneration that both allow for neutral pH degradation products and have the ability to nucleate bonelike apatite. In this study, the etheric biodegradable polyphosphazene, poly[(50%-ethyl glycinato) (50%methoxyethoxyethoxy)phosphazene] (PNEG50MEEP50) was blended with poly(lactide-co-glycolide) PLAGA and studied their ability to produce high-strength degradable biomaterials with bioactivity. Accordingly, two blends with weight ratios of PNEG50MEEP50 to PLAGA 25:75 (BLEND25) and 50:50 (BLEND50) were fabricated using a mutual solvent approach. Increases in PNEG50MEEP50 content in the blend system resulted in decreased elastic modulus of 779 MPa when compared with 1684 MPa (PLAGA) as well as tensile strength 7.9 MPa when compared with 25.7 MPa (PLAGA). However, the higher PNEG50MEEP50 content in the blend system resulted in higher Ca/P atomic ratio of the apatite layer 1.35 (BLEND50) when compared with 0.69 (BLEND25) indicating improved biomimicry. Furthermore, these blends supported primary rat osteoblast adhesion and proliferation with an enhanced phenotypic expression when compared with PLAGA. These findings establish the suitability of PNEG50MEEP50-PLAGA biodegradable blends as promising bioactive materials for orthopedic applications.

Original languageEnglish (US)
Pages (from-to)114-125
Number of pages12
JournalJournal of Biomedical Materials Research - Part A
Volume92
Issue number1
DOIs
StatePublished - Jan 1 2010

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All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

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