Biomimetic Separation of Transport and Matrix Functions in Lamellar Block Copolymer Channel-Based Membranes

Chao Lang, Dan Ye, Woochul Song, Chenhao Yao, Yu Ming Tu, Clara Capparelli, Jacob A. Lanasa, Michael Anthony Hickner, Esther Winter Gomez, Enrique Daniel Gomez, Robert John Hickey, III, Manish Kumar

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Cell membranes control mass, energy, and information flow to and from the cell. In the cell membrane a lipid bilayer serves as the barrier layer, with highly efficient molecular machines, membrane proteins, serving as the transport elements. In this way, highly specialized transport properties are achieved by these composite materials by segregating the matrix function from the transport function using different components. For example, cell membranes containing aquaporin proteins can transport -4 billion water molecules per second per aquaporin while rejecting all other molecules including salts, a feat unmatched by any synthetic system, while the impermeable lipid bilayer provides the barrier and matrix properties. True separation of functions between the matrix and the transport elements has been difficult to achieve in conventional solute separation synthetic membranes. In this study, we created membranes with distinct matrix and transport elements through designed coassembly of solvent-stable artificial (peptide-appended pillar[5]arene, PAP5) or natural (gramicidin A) model channels with block copolymers into lamellar multilayered membranes. Self-assembly of a lamellar structure from cross-linkable triblock copolymers was used as a scalable replacement for lipid bilayers, offering better stability and mechanical properties. By coassembly of channel molecules with block copolymers, we were able to synthesize nanofiltration membranes with sharp selectivity profiles as well as uncharged ion exchange membranes exhibiting ion selectivity. The developed method can be used for incorporation of different artificial and biological ion and water channels into synthetic polymer membranes. The strategy reported here could promote the construction of a range of channel-based membranes and sensors with desired properties, such as ion separations, stimuli responsiveness, and high sensitivity.

Original languageEnglish (US)
Pages (from-to)8292-8302
Number of pages11
JournalACS nano
Volume13
Issue number7
DOIs
StatePublished - Jul 23 2019

Fingerprint

biomimetics
Biomimetics
block copolymers
Block copolymers
Aquaporins
Lipid bilayers
membranes
Membranes
Cell membranes
matrices
Molecules
lipids
Ions
Gramicidin
Nanofiltration membranes
Ion exchange membranes
Lamellar structures
Proteins
Ion Channels
selectivity

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Lang, C., Ye, D., Song, W., Yao, C., Tu, Y. M., Capparelli, C., ... Kumar, M. (2019). Biomimetic Separation of Transport and Matrix Functions in Lamellar Block Copolymer Channel-Based Membranes. ACS nano, 13(7), 8292-8302. https://doi.org/10.1021/acsnano.9b03659
Lang, Chao ; Ye, Dan ; Song, Woochul ; Yao, Chenhao ; Tu, Yu Ming ; Capparelli, Clara ; Lanasa, Jacob A. ; Hickner, Michael Anthony ; Gomez, Esther Winter ; Gomez, Enrique Daniel ; Hickey, III, Robert John ; Kumar, Manish. / Biomimetic Separation of Transport and Matrix Functions in Lamellar Block Copolymer Channel-Based Membranes. In: ACS nano. 2019 ; Vol. 13, No. 7. pp. 8292-8302.
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Biomimetic Separation of Transport and Matrix Functions in Lamellar Block Copolymer Channel-Based Membranes. / Lang, Chao; Ye, Dan; Song, Woochul; Yao, Chenhao; Tu, Yu Ming; Capparelli, Clara; Lanasa, Jacob A.; Hickner, Michael Anthony; Gomez, Esther Winter; Gomez, Enrique Daniel; Hickey, III, Robert John; Kumar, Manish.

In: ACS nano, Vol. 13, No. 7, 23.07.2019, p. 8292-8302.

Research output: Contribution to journalArticle

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AU - Lang, Chao

AU - Ye, Dan

AU - Song, Woochul

AU - Yao, Chenhao

AU - Tu, Yu Ming

AU - Capparelli, Clara

AU - Lanasa, Jacob A.

AU - Hickner, Michael Anthony

AU - Gomez, Esther Winter

AU - Gomez, Enrique Daniel

AU - Hickey, III, Robert John

AU - Kumar, Manish

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