Biomineralization in humans

Making the hard choices in life

Kazuhiko Kawasaki, Anne Buchanan Weiss, Kenneth M. Weiss

Research output: Contribution to journalReview article

87 Citations (Scopus)

Abstract

The skeleton, teeth, and otoconia are normally the only mineralized tissues or organs in the human body. We describe physiological biomineralization in collagenous matrices as well as a more derived noncollagenous matrix. The origin of the collagenous matrices used in mineralized skeletal tissues can be traced to a soft tissue in early Metazoa. In early vertebrates, a genetic system coding for ancient soft collagenous tissue was co-opted for biomineralization using redundant genes resulting from whole genome duplication. However, genes more specific to mineralized tissues arose subsequent to the genome duplication by genomically local tandem duplication. These new genes are the basis for a novel genetic system for various mineralized tissues in skeleton and teeth. In addition, any tissue can be abnormally mineralized, and many pathologies of mineralization in humans are known.

Original languageEnglish (US)
Pages (from-to)119-142
Number of pages24
JournalAnnual review of genetics
Volume43
DOIs
StatePublished - Dec 1 2009

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Skeleton
Tooth
Genome
Genes
Otolithic Membrane
Human Body
Vertebrates
Pathology

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Kawasaki, Kazuhiko ; Weiss, Anne Buchanan ; Weiss, Kenneth M. / Biomineralization in humans : Making the hard choices in life. In: Annual review of genetics. 2009 ; Vol. 43. pp. 119-142.
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Biomineralization in humans : Making the hard choices in life. / Kawasaki, Kazuhiko; Weiss, Anne Buchanan; Weiss, Kenneth M.

In: Annual review of genetics, Vol. 43, 01.12.2009, p. 119-142.

Research output: Contribution to journalReview article

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