Biomolecular hydrogel-based lipid bilayer array system

Joseph Najem, Alex Edgerton, Donald J. Leo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

This work investigates the fabrication of hydrogel based lipid bilayers arrays using micro fabrication technologies that enable high precision in controlling the cell-scale droplets. Arrays of hydrogels that support curved aqueous lenses are deposited on two parallel substrates using lithography techniques on top of a network of Ag/AgCl electrodes. The first step in the fabrication process is to deposit silver electrodes using silver paint through a mask, a layer of silver chloride is then formed around the silver channels using another mask with the desired geometry. The hydrogel arrays are then achieved by exposing a thin film of photocrosslinkable hydrogel to UV light through a mask. Hydrogel arrays are fabricated using this technique, which is represents a relatively accurate and inexpensive method. The hydrogel structures can host a thin aqueous curved lenses containing phospholipids . Bilayer arrays can be formed by using a technique similar to the regulated attachment method, where mechanical force is used to bring adjacent aqueous lenses in contact.

Original languageEnglish (US)
Title of host publicationBioinspiration, Biomimetics, and Bioreplication 2013
DOIs
StatePublished - Jun 4 2013
EventBioinspiration, Biomimetics, and Bioreplication 2013 - San Diego, CA, United States
Duration: Mar 11 2013Mar 13 2013

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume8686
ISSN (Print)0277-786X

Other

OtherBioinspiration, Biomimetics, and Bioreplication 2013
CountryUnited States
CitySan Diego, CA
Period3/11/133/13/13

Fingerprint

Hydrogel
Lipid Bilayer
Lipid bilayers
Hydrogels
lipids
Silver
Masks
Lenses
masks
Mask
silver
lenses
Lens
Silver deposits
fabrication
Fabrication
Electrodes
Electrode
Microfabrication
silver chlorides

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Najem, J., Edgerton, A., & Leo, D. J. (2013). Biomolecular hydrogel-based lipid bilayer array system. In Bioinspiration, Biomimetics, and Bioreplication 2013 [86860C] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 8686). https://doi.org/10.1117/12.2010695
Najem, Joseph ; Edgerton, Alex ; Leo, Donald J. / Biomolecular hydrogel-based lipid bilayer array system. Bioinspiration, Biomimetics, and Bioreplication 2013. 2013. (Proceedings of SPIE - The International Society for Optical Engineering).
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Najem, J, Edgerton, A & Leo, DJ 2013, Biomolecular hydrogel-based lipid bilayer array system. in Bioinspiration, Biomimetics, and Bioreplication 2013., 86860C, Proceedings of SPIE - The International Society for Optical Engineering, vol. 8686, Bioinspiration, Biomimetics, and Bioreplication 2013, San Diego, CA, United States, 3/11/13. https://doi.org/10.1117/12.2010695

Biomolecular hydrogel-based lipid bilayer array system. / Najem, Joseph; Edgerton, Alex; Leo, Donald J.

Bioinspiration, Biomimetics, and Bioreplication 2013. 2013. 86860C (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 8686).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Najem J, Edgerton A, Leo DJ. Biomolecular hydrogel-based lipid bilayer array system. In Bioinspiration, Biomimetics, and Bioreplication 2013. 2013. 86860C. (Proceedings of SPIE - The International Society for Optical Engineering). https://doi.org/10.1117/12.2010695