Biophysical and computational methods to analyze amino acid interaction networks in proteins

Kathleen F. O'Rourke, Scott D. Gorman, David D. Boehr

Research output: Contribution to journalShort survey

12 Citations (Scopus)

Abstract

Globular proteins are held together by interacting networks of amino acid residues. A number of different structural and computational methods have been developed to interrogate these amino acid networks. In this review, we describe some of these methods, including analyses of X-ray crystallographic data and structures, computer simulations, NMR data, and covariation among protein sequences, and indicate the critical insights that such methods provide into protein function. This information can be leveraged towards the design of new allosteric drugs, and the engineering of new protein function and protein regulation strategies.

Original languageEnglish (US)
Pages (from-to)245-251
Number of pages7
JournalComputational and Structural Biotechnology Journal
Volume14
DOIs
StatePublished - Jan 1 2016

Fingerprint

Protein Interaction Maps
Computational methods
Amino acids
Proteins
Amino Acids
Protein Engineering
Computer Simulation
X-Rays
Nuclear magnetic resonance
X rays
Pharmaceutical Preparations
Computer simulation

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biophysics
  • Structural Biology
  • Biochemistry
  • Genetics
  • Computer Science Applications

Cite this

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Biophysical and computational methods to analyze amino acid interaction networks in proteins. / O'Rourke, Kathleen F.; Gorman, Scott D.; Boehr, David D.

In: Computational and Structural Biotechnology Journal, Vol. 14, 01.01.2016, p. 245-251.

Research output: Contribution to journalShort survey

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