Bioprinting towards Physiologically Relevant Tissue Models for Pharmaceutics

Weijie Peng, Derya Unutmaz, Ibrahim T. Ozbolat

Research output: Contribution to journalReview article

62 Citations (Scopus)

Abstract

Improving the ability to predict the efficacy and toxicity of drug candidates earlier in the drug discovery process will speed up the introduction of new drugs into clinics. 3D in vitro systems have significantly advanced the drug screening process as 3D tissue models can closely mimic native tissues and, in some cases, the physiological response to drugs. Among various in vitro systems, bioprinting is a highly promising technology possessing several advantages such as tailored microarchitecture, high-throughput capability, coculture ability, and low risk of cross-contamination. In this opinion article, we discuss the currently available tissue models in pharmaceutics along with their limitations and highlight the possibilities of bioprinting physiologically relevant tissue models, which hold great potential in drug testing, high-throughput screening, and disease modeling.

Original languageEnglish (US)
Pages (from-to)722-732
Number of pages11
JournalTrends in Biotechnology
Volume34
Issue number9
DOIs
StatePublished - Sep 1 2016

Fingerprint

Bioprinting
Tissue
Pharmaceutical Preparations
Screening
Throughput
Preclinical Drug Evaluations
Drug Discovery
Coculture Techniques
Drug-Related Side Effects and Adverse Reactions
Toxicity
Contamination
Technology
Testing

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering

Cite this

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Bioprinting towards Physiologically Relevant Tissue Models for Pharmaceutics. / Peng, Weijie; Unutmaz, Derya; Ozbolat, Ibrahim T.

In: Trends in Biotechnology, Vol. 34, No. 9, 01.09.2016, p. 722-732.

Research output: Contribution to journalReview article

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