Bioprocess membrane technology

Robert van Reis, Andrew Zydney

Research output: Contribution to journalReview article

414 Citations (Scopus)

Abstract

Membrane processes play a critical role in the purification of biotechnology products. Early membrane systems were adopted from technology originally developed for other industrial applications. During the last 2 decades, new membranes and modules have been developed specifically to meet the requirements of the biotechnology industry. This includes applications of membranes for sterile filtration, clarification, initial harvest, virus removal, protein concentration, buffer exchange, and protein purification. This manuscript provides an overview of recent developments in membrane technology, focusing on the special characteristics of the membrane systems that are now used for the commercial production and purification of recombinant protein products. Future developments in membrane technology are also discussed that may be able to meet the growing needs for higher productivity, lower cost of production, and increased development speed in the biotechnology industry.

Original languageEnglish (US)
Pages (from-to)16-50
Number of pages35
JournalJournal of Membrane Science
Volume297
Issue number1-2
DOIs
StatePublished - Jul 5 2007

Fingerprint

Membrane technology
membranes
Technology
Membranes
Biotechnology
Purification
biotechnology
purification
proteins
Proteins
Recombinant proteins
Industry
industries
Viruses
Recombinant Proteins
Industrial applications
Ion exchange
Buffers
viruses
Productivity

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Materials Science(all)
  • Physical and Theoretical Chemistry
  • Filtration and Separation

Cite this

van Reis, Robert ; Zydney, Andrew. / Bioprocess membrane technology. In: Journal of Membrane Science. 2007 ; Vol. 297, No. 1-2. pp. 16-50.
@article{5c814ee63a7b4ff69c505104472cfcda,
title = "Bioprocess membrane technology",
abstract = "Membrane processes play a critical role in the purification of biotechnology products. Early membrane systems were adopted from technology originally developed for other industrial applications. During the last 2 decades, new membranes and modules have been developed specifically to meet the requirements of the biotechnology industry. This includes applications of membranes for sterile filtration, clarification, initial harvest, virus removal, protein concentration, buffer exchange, and protein purification. This manuscript provides an overview of recent developments in membrane technology, focusing on the special characteristics of the membrane systems that are now used for the commercial production and purification of recombinant protein products. Future developments in membrane technology are also discussed that may be able to meet the growing needs for higher productivity, lower cost of production, and increased development speed in the biotechnology industry.",
author = "{van Reis}, Robert and Andrew Zydney",
year = "2007",
month = "7",
day = "5",
doi = "10.1016/j.memsci.2007.02.045",
language = "English (US)",
volume = "297",
pages = "16--50",
journal = "Journal of Membrane Science",
issn = "0376-7388",
publisher = "Elsevier",
number = "1-2",

}

Bioprocess membrane technology. / van Reis, Robert; Zydney, Andrew.

In: Journal of Membrane Science, Vol. 297, No. 1-2, 05.07.2007, p. 16-50.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Bioprocess membrane technology

AU - van Reis, Robert

AU - Zydney, Andrew

PY - 2007/7/5

Y1 - 2007/7/5

N2 - Membrane processes play a critical role in the purification of biotechnology products. Early membrane systems were adopted from technology originally developed for other industrial applications. During the last 2 decades, new membranes and modules have been developed specifically to meet the requirements of the biotechnology industry. This includes applications of membranes for sterile filtration, clarification, initial harvest, virus removal, protein concentration, buffer exchange, and protein purification. This manuscript provides an overview of recent developments in membrane technology, focusing on the special characteristics of the membrane systems that are now used for the commercial production and purification of recombinant protein products. Future developments in membrane technology are also discussed that may be able to meet the growing needs for higher productivity, lower cost of production, and increased development speed in the biotechnology industry.

AB - Membrane processes play a critical role in the purification of biotechnology products. Early membrane systems were adopted from technology originally developed for other industrial applications. During the last 2 decades, new membranes and modules have been developed specifically to meet the requirements of the biotechnology industry. This includes applications of membranes for sterile filtration, clarification, initial harvest, virus removal, protein concentration, buffer exchange, and protein purification. This manuscript provides an overview of recent developments in membrane technology, focusing on the special characteristics of the membrane systems that are now used for the commercial production and purification of recombinant protein products. Future developments in membrane technology are also discussed that may be able to meet the growing needs for higher productivity, lower cost of production, and increased development speed in the biotechnology industry.

UR - http://www.scopus.com/inward/record.url?scp=34248591731&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34248591731&partnerID=8YFLogxK

U2 - 10.1016/j.memsci.2007.02.045

DO - 10.1016/j.memsci.2007.02.045

M3 - Review article

AN - SCOPUS:34248591731

VL - 297

SP - 16

EP - 50

JO - Journal of Membrane Science

JF - Journal of Membrane Science

SN - 0376-7388

IS - 1-2

ER -