Biotin and the nucleophilicity of 2-methoxy-2-imidazoline toward the sp2 carbonyl carbon

A. F. Hegarty, Thomas C. Bruice, Stephen J. Benkovic

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

A model for the biotin tautomer, 2-methoxy-2-imidazoline, possesses a nucleophilicity toward the sp2 carbonyl carbon 1010-fold greater than the previously considered 2-imidazolidone.

Original languageEnglish (US)
Pages (from-to)1173-1174
Number of pages2
JournalAnalytical Proceedings
DOIs
StatePublished - 1969

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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