Biphasic expression and function of glucose dehydrogenase in Drosophila melanogaster

D. R. Cavener, R. J. MacIntyre

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Glucose dehydrogenase (GO) was found to be expressed during the pupal stage in both sexes of Drosophila melanogaster, but is limited to the male ejaculatory duct at the adult stage. During copulation GO is transferred from males to females. Mutational analysis of the Go locus indicates that a single structural gene encodes the pupal and ejaculatory duct GO. Thus an example of an enzyme structural gene switching from non-sex-limited to sex-limited expression has been found. Go mutants are recessive lethals exhibiting a late pupal effective lethal phase. These mutants can be rescued by excising the anterior end of the pupal case 0-2 days prior to the normal adult emergence time. It appears that the function of GO in pupae is to aid in the degradation of the puparium cuticle in preparation for the eclosion of the adult.

Original languageEnglish (US)
Pages (from-to)6286-6288
Number of pages3
JournalProceedings of the National Academy of Sciences of the United States of America
Volume80
Issue number20 I
DOIs
StatePublished - Jan 1 1983

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Glucose 1-Dehydrogenase
Drosophila melanogaster
Ejaculatory Ducts
Copulation
Pupa
Genes
Enzymes

All Science Journal Classification (ASJC) codes

  • General

Cite this

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abstract = "Glucose dehydrogenase (GO) was found to be expressed during the pupal stage in both sexes of Drosophila melanogaster, but is limited to the male ejaculatory duct at the adult stage. During copulation GO is transferred from males to females. Mutational analysis of the Go locus indicates that a single structural gene encodes the pupal and ejaculatory duct GO. Thus an example of an enzyme structural gene switching from non-sex-limited to sex-limited expression has been found. Go mutants are recessive lethals exhibiting a late pupal effective lethal phase. These mutants can be rescued by excising the anterior end of the pupal case 0-2 days prior to the normal adult emergence time. It appears that the function of GO in pupae is to aid in the degradation of the puparium cuticle in preparation for the eclosion of the adult.",
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Biphasic expression and function of glucose dehydrogenase in Drosophila melanogaster. / Cavener, D. R.; MacIntyre, R. J.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 80, No. 20 I, 01.01.1983, p. 6286-6288.

Research output: Contribution to journalArticle

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